Voi Shim Wong

Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581]

Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay et autres

Backgrounds & aims: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide …

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An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay et autres

BACKGROUNDS & AIMS: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide …

gb, jp, cn, us, it, ca (code pays fourni par la source)

X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Rosanna Asselta, Elvezia Maria Paraboschi, Alessio Gerussi, Heather J. Cordell et autres

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Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score

Marco Carbone, Alessandra Nardi, Steve Flack, Guido Carpino et autres

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PTU-115 Intravenous iron is effective in reducing the need for blood transfusion in acute medical settings

Sheena Mankodi, D Nissan, Voi Shim Wong, Anthony Lerman

Introduction Blood transfusions are necessary for patients with significant symptomatic anaemia in acute medical settings. However, the increasing use and availability of intravenous (IV) iron in these patients may reduce the frequency of blood transfusion and its attendant risks. Our aim was …

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International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Heather J. Cordell, Younghun Han, George Mells, Yafang Li et autres

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in …

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Acute drug induced hepatitis secondary to a weight loss product purchased over the internet

Deepak Joshi, Tim Cross, Voi Shim Wong

BACKGROUND: Many people now seek alternative methods of weight loss. The internet provides a readily available source of weight reduction products, the ingredients of which are often unclear. The authors describe a case of acute hepatitis in a 20 year old woman …

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Naltrexone: report of lack of hepatotoxicity in acute viral hepatitis, with a review of the literature

Colin Brewer, Voi Shim Wong

Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers. Some much-quoted early studies noted abnormalities …

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Day case liver biopsy — A single center experience

Venkatraman S. Raman, Voi Shim Wong, Martin Lombard

What proportion of dyspeptic patients having H.pylori breath test subsequently undergo endoscopy?

Kalpesh Besherdas, Jude A. Oben, Eric Beck, Robin Vicary et autres

Hepatic sarcoidosis complicated by hepatocellular carcinoma

Voi Shim Wong, Naghme Adab, Giles R. Youngs, Richard Sturgess

A case of a 63-year-old man with a long-standing history of portal hypertension secondary to hepatic sarcoidosis who developed hepatocellular carcinoma is reported.

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The role for liver biopsy in haemophiliacs infected with the hepatitis C virus

Voi Shim Wong, Trevor Baglin, Emma Beacham, DEREK D. G. WIGHT et autres

Assessment of chronic hepatitis C virus infection requires a liver biopsy in most circumstances. There is a reluctance to perform liver biopsy in haemophiliacs because of a perceived risk of haemorrhage, although with adequate factor concentrate replacement in patients without factor concentrate …

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