Colin Brewer

Fentanyl-blocking effects of extended-release naltrexone in humans: Three case reports

Colin Brewer

Despite the contribution of the µ-agonist fentanyl to the United States's opiate overdose epidemic, no human studies specifically address the ability of extended-release preparations of the opiate antagonist naltrexone (NTX) to block fentanyl's life-threatening µ-agonist-mediated respiratory depression. This paper presents three case …

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Disulfiram Treatment for Alcohol Abuse

Colin Brewer, Emmanuel Streel

Assisted deaths in Switzerland for UK residents: diagnoses and their implications for palliative medicine and assisted dying legislation

Colin Brewer, Marie-Claire Hopwood, Graham Winyard

OBJECTIVE: UK campaigners for a law permitting assisted dying (AD) restricted to those with a maximum life expectancy of 6 months claim that this would largely remove the need for UK residents to seek AD in Switzerland. We wanted to discover whether …

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Optimising Patient Care Using Naltrexone for Opioid Use Disorders

Colin Brewer

The opiate antagonist naltrexone (NTX) was specifically developed as a possible alternative to methadone maintenance for treating opiate dependence. Though it can completely block the agonist effects of even very large doses of opiates, poor compliance with oral NTX limited its potential. …

Covid-19 and suicide: lessons from the Blitz

Colin Brewer

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Leaving Life Too Early or Leaving the Decision Too Late in Alzheimer-Type Dementias: Choices and Preferences for Medical Assistance in Dying (MAID)

Colin Brewer

Novel Biological and Mechanical Analysis Techniques for Alcohol and Other Drugs of Abuse: Their Role in Addiction Management and Psychiatric Treatment

Colin Brewer

Because alcohol is by far the most widely abused drug in western societies and in many developing countries, this chapter begins with methods of detecting alcohol and monitoring alcohol intake. The very rapid excretion of alcohol and the lack of any longer …

A novel early mobility bundle improves length of stay and rates of readmission among hospitalized general medicine patients

Emily Anne Smith Bergbower, Cole Herbst, Nan Cheng, Alexander Aversano et autres

Inpatient early mobility initiatives are effective therapeutic interventions for improving patient outcomes and decreasing use of hospital resources among adult ICU and general medicine patients. To establish and demonstrate guidelines for early patient ambulation, we developed and implemented a novel multidisciplinary mobility …

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Is Alcohol in Hand Sanitizers Absorbed Through the Skin or Lungs? Implications for Disulfiram Treatment

Colin Brewer, Emmanuel Streel

AIM: In view of the increase in the use of ethanol-containing hand sanitizers throughout the world due to the current COVID-19 pandemic, we wished to review the possible risks to patients treated with disulfiram, following a case report in which an apparent …

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Max Rendall: consultant surgeon who became an addiction specialist in retirement

Colin Brewer

Max Rendall, who has died at the age of 85, was a consultant surgeon and superintendent at Guy’s Hospital, London. In retirement, he developed a second career in addiction medicine and wrote a book criticising the century old “noble experiment” of outlawing …

Partial ALDH inhibition to facilitate controlled drinking rather than abstinence has already been tried and it works

Colin Brewer

Following animal studies, Guillot et al. (1) suggest that partial inhibition of aldehyde dehydrogenase (ALDH) might prove useful in alcoholism treatment aimed at moderating drinking, rather than preventing it, but their paper does not recognize that this approach has already been shown …

Response to Darke et al . (2019): Circumstances of death of opioid users being treated with naltrexone

Emmanuel Streel, Colin Brewer

Sir: Although Darke et al. 1 state correctly that ‘compliance with oral naltrexone (NTX) poses particular clinical challenges', they ignore several important issues. They did not mention any studies in which supervised oral administration, by family members or probation/parole staff, achieved persistently …

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