Sonja J. Pyott

Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus

Nick M. A. Schubert, Shuyang Yao, Maryam Kazemi Naeini, Natalia Trpchevska et autres

Tinnitus is a distressing condition affecting millions of people worldwide, yet treatment options remain very limited. Molecular evidence on the cellular origins of tinnitus in humans is lacking. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported tinnitus on …

nl, se, gb, us, fi, dk, it, is, ee, de (code pays fourni par la source)

Hyperacusis is Associated with Smaller Gray Matter Volumes in the Supplementary Motor Area

Punitkumar Makani, Elouise A. Koops, Sonja J. Pyott, Pim van Dijk et autres

nl (code pays fourni par la source)

Hyperacusis is associated with smaller gray matter volumes in the supplementary motor area

Punitkumar Makani, Elouise A. Koops, Sonja J. Pyott, Pim van Dijk et autres

Hyperacusis is a disorder in loudness perception characterized by increased sensitivity to ordinary environmental sounds and associated with otologic conditions, including hearing loss and tinnitus (the phantom perception of sound) as well as neurologic and neuropsychiatric conditions. Hyperacusis is believed to arise …

nl, us (code pays fourni par la source)

What the African naked mole-rat can tell us about mammalian hearing and acoustic communication

Catherine M. Barone, Thomas Park, Sonja J. Pyott

African naked mole-rats are eusocial rodents that live underground in narrow burrows. Likely reflecting adaptations to their subterranean environment, naked mole-rats (NMRs) have poor high frequency hearing, relatively high auditory thresholds, and limited ability to localize sound thus providing a unique opportunity …

us, nl (code pays fourni par la source)

mGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea

Zhanlei Ye, Juan D. Goutman, Sonja J. Pyott, Elisabeth Glowatzki

KEY POINTS: Spontaneous activity of the sensory inner hair cells shapes maturation of the developing ascending (afferent) auditory system before hearing begins. Just before the onset of hearing, descending (efferent) input from cholinergic neurons originating in the brainstem inhibit inner hair cell …

us, ar, nl (code pays fourni par la source)

Whole-Cell Patch-Clamp Recording of Mouse and Rat Inner Hair Cells in the Intact Organ of Corti

Juan D. Goutman, Sonja J. Pyott

ar, nl (code pays fourni par la source)

Current Understanding of the Circadian Clock Within Cnidaria

Kenneth D. Hoadley, Peter D. Vize, Sonja J. Pyott

us, ca, nl (code pays fourni par la source)

Hair Cell Ribbon Synapse Function - Differently Optimized for Hearing and Balance

Soroush G. Sadeghi, Sonja J. Pyott, Yu Zhou, Elisabeth Glowatzki

us, nl (code pays fourni par la source)

Glutamatergic Signaling at the Vestibular Hair Cell Calyx Synapse

Soroush G. Sadeghi, Sonja J. Pyott, Yu Zhou, Elisabeth Glowatzki

In the vestibular periphery a unique postsynaptic terminal, the calyx, completely covers the basolateral walls of type I hair cells and receives input from multiple ribbon synapses. To date, the functional role of this specialized synapse remains elusive. There is limited data …

nl, us (code pays fourni par la source)

Circadian Clock Gene Expression in the Coral Favia fragum over Diel and Lunar Reproductive Cycles

Kenneth D. Hoadley, Alina M. Szmant, Sonja J. Pyott

Natural light cycles synchronize behavioral and physiological cycles over varying time periods in both plants and animals. Many scleractinian corals exhibit diel cycles of polyp expansion and contraction entrained by diel sunlight patterns, and monthly cycles of spawning or planulation that correspond …

us (code pays fourni par la source)

Ca2+and Ca2+-Activated K+Channels That Support and Modulate Transmitter Release at the Olivocochlear Efferent–Inner Hair Cell Synapse

Javier Zorrilla de San Martín, Sonja J. Pyott, Jimena A. Ballestero, Eleonora Katz

In the mammalian auditory system, the synapse between efferent olivocochlear (OC) neurons and sensory cochlear hair cells is cholinergic, fast, and inhibitory. This efferent synapse is mediated by the nicotinic alpha9alpha10 receptor coupled to the activation of SK2 Ca(2+)-activated K(+) channels that …

ar, us (code pays fourni par la source)

The Role of Cryptochrome Photoreceptors in Regulation of Favia fragum Diel and Lunar Reproductive Cycle

Kenneth D. Hoadley, Alina M. Szmant, Sonja J. Pyott