Weihong Song

Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation.

Zhao Wang, Wei Dong, Xiangling Feng, Xinran Xu et autres

expression and aberrant T cell hyperactivation. Our integrative and context-dependent strategy establishes a comprehensive pathway for deciphering the missing regulatory mechanisms of complex disease.

cn, pl, hk (code pays fourni par la source)

Efficacy and safety of efsubaglutide alfa in individuals with type 2 diabetes (SUPER1): a randomised, double-blind, placebo-controlled, Phase IIb/III trial

Dalong Zhu, Jianhua Ma, Weimin Wang, Bi‐Min Shi et autres

cn, us (code pays fourni par la source)

Biomarkers of ageing of humans and non-human primates

Zeming Wu, Jing Tao Qu, Weiqi Zhang, Zhijun Bao et autres

cn, in, Éthiopie, hk, us, mx (code pays fourni par la source)

Efficacy and safety of chiglitazar add‐on to metformin in type 2 diabetes mellitus ( RECAM study)

Leili Gao, Linong Ji, Xin Yan, Zhifeng Cheng et autres

AIMS: Chiglitazar is a novel peroxisome proliferator-activated receptor pan-agonist regulating glucose and lipid metabolism. The RECAM study aimed to evaluate the efficacy and safety of chiglitazar add-on therapy to metformin in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: In …

cn (code pays fourni par la source)

Smoking impairs cognitive function through the mediating effect of periodontitis in older adults

Xiaoqian Luan, Jin Zhou, Jin Li, Yao An et autres

OBJECTIVES: Evidence has shown that both smoking and periodontitis were linked to cognitive impairment. This study examines whether periodontitis mediates the effects of smoking status on cognitive function in older adults. METHODS: Using data from the National Health and Nutrition Examination Survey …

cn (code pays fourni par la source)

One-pot three-component synthesis of benzo[ h ]isoquinolin-3-ones via rhodium( iii )-catalyzed C–H activation

Weihong Song, Xiaomei Jiang, Weiguo Yu, Ziwei Xiang

A Rh( iii )-catalyzed synthesis of unprecedented benzo[ h ]isoquinolin-3-ones from 1-naphthaldehyde, aniline and diazo compounds in one pot has been realized with an imine as the directing group which was generated from aldimine condensation in situ .

cn, cz (code pays fourni par la source)

A biweekly DPP ‐4 inhibitor cofrogliptin monotherapy in Chinese patients with impaired glucose tolerance: A phase 2, multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group trial

Qinghua He, Zhifeng Cheng, Yufeng Li, Xiaoyan Xing et autres

Abstract Aims To assess the efficacy and safety of cofrogliptin for impaired glucose tolerance (IGT). Methods In this multicenter, double‐blind, placebo‐controlled phase 2 trial, IGT patients were randomized 1:1:1 to receive cofrogliptin 10 mg, cofrogliptin 25 mg or placebo once biweekly. The …

cn (code pays fourni par la source)

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

Shuai Ma, Zhejun Ji, Bin Zhang, Lingling Geng et autres

cn, in, us (code pays fourni par la source)

Metformin decelerates aging clock in male monkeys

Xiaoyong Lu, Ning Liu, Shuai Ma, Hui Zhang et autres

cn, us (code pays fourni par la source)

SLC44A2-mediated phenotypic switch of vascular smooth muscle cells contributes to aortic aneurysm

Mengen Xing, Wanqi Chen, Yachen Ji, Weihong Song

The phenotypic switch of vascular smooth cells (VSMCs) from a contractile to a synthetic state is associated with the development and progression of aortic aneurysm (AA). However, the mechanism underlying this process remains unclear. In this issue of the JCI, Song et …

cn (code pays fourni par la source)

Alpha-lipoic acid alleviates cognitive deficits in transgenic APP23/PS45 mice through a mitophagy-mediated increase in ADAM10 α-secretase cleavage of APP

Jie Zhang, Yanshuang Jiang, Xiangjun Dong, Zijun Meng et autres

BACKGROUND: Alpha-lipoic acid (ALA) has a neuroprotective effect on neurodegenerative diseases. In the clinic, ALA can improve cognitive impairments in patients with Alzheimer's disease (AD) and other dementias. Animal studies have confirmed the anti-amyloidosis effect of ALA, but its underlying mechanism remains …

cn (code pays fourni par la source)

733-P: Efficacy and Safety of HS-20094 in Patients with Type 2 Diabetes—A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial

Lin Liu, XIAOXIA SHI, Fei He, Zhifeng Cheng et autres

Introduction and Objective: HS-20094 is a novel dual GIP and GLP-1 receptor agonist. A 4-week POC study was conducted to assess the preliminary efficacy and safety of HS-20094 in patients with type 2 diabetes (T2DM). Methods: This was a randomized, double-blind, placebo-controlled …