K. P. Srikanth

New class of dual agonistic T-cell engagers for the in-patient activation and expansion of v delta 1 T cells with broad antigen agnostic antitumour activity

André Simoes, Jarek Juraszek, Giulio Bocconcelli, K. P. Srikanth et autres

Abstract Introduction: Gamma Delta (γδ) T cells have gained broad scientific recognition as a third subset of lymphocytes with a distinct and evolutionary conserved role in the recognition of malignant cells. Especially γδ T cells bearing a V delta 1 T cell …

Generalised granuloma annulare in a child with Alagille syndrome with a novel mutation

N Aishwarya, Divya Gupta, K. P. Srikanth, Jatin K Reddy et autres

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Natural course and outcomes of children with ubiquitin‐specific protease 53 (USP53)‐related genetic chronic cholestasis

Seema Alam, Bikrant Bihari Lal, Aathira Ravindranath, Ashish Bavdekar et autres

Ubiquitin-specific protease 53 (USP53) is essential for formation of cellular tight junctions and variations in this gene disrupt the tight junctions, resulting in cholestasis. We describe the clinical manifestations and outcomes of patients with USP53 mutations from the Indian progressive familial intrahepatic …

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Tunneled Dialysis Catheter Insertion in External Jugular Vein by Nephrologists

Vineet Behera, Shahbaj Ahmad, Smriti Sinha, Gireesh Reddy G et autres

Background: External jugular vein (EJV) is used to insert tunneled dialysis catheter (TDC) in patients with no AVF and exhausted right internal jugular veins (IJV). There is scarce data on TDC insertion in EJV by nephrologists with fluoroscopy guidance. Materials and Methods: …

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Genotype correlates with clinical course and outcome of children with tight junction protein 2 (TJP2) deficiency–related cholestasis

Bikrant Bihari Lal, Anupam Sibal, Karunesh Kumar, Somashekara Hosaagrahara Ramakrishna et autres

BACKGROUND AND AIMS: The study aimed to describe the clinical course and outcomes, and analyze the genotype-phenotype correlation in patients with tight junction protein 2 (TJP2) deficiency. APPROACH AND RESULTS: Data from all children with chronic cholestasis and either homozygous or compound …

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Therapeutic Enteral Formulas in Children

John Matthai, Neelam Mohan, Meera Sushila Viswanathan, Naresh P Shanmugam et autres

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Clinical Spectrum and Outcome of Gallstones in Children and Adolescents

Subhamoy Das, Babu Ram Thapa, Sadhna Bhasin Lal, K. P. Srikanth

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Spectrum of Pediatric Wilson Disease From a Non-transplant Tertiary Care Center in North India

Jagadeesh Menon, Babu Ram Thapa, K. P. Srikanth, Shruti Sharma et autres

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Unusual Cause and Association of Gastrointestinal Bleed in a Young Boy

K. P. Srikanth, B. R. Thapa, Ravi P. Kanojia, Kim Vaiphei et autres

ABSTRACT A 4-year old child, previously operated case of tetralogy of Fallot present with recurrent episodes of massive lower gastrointestinal bleed of one year duration. Endoscopic evaluation revealed multiple bluish vascular lesions in the duodenum and proximal jejunum and a single rectal …

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Multifocal hepatic abscess with community acquired Citrobacter koseri infection causing liver failure in an immune competent child

K. P. Srikanth

Multifocal hepatic abscess with community acquired Citrobacter koseri infection causing liver failure in an immune competent child Liver abscess is one of the deep seated abscess and serious infection requiring hospitalization in children.Pyogenic abscesses are more common than amebic abscesses.Various gram positive, …

VASCULAR ENDOTHELIAL GROWTH FACTOR IN HEALTH AND DISEASE: A REVIEW

Niranjan Gopal, Srinivasan A. R, Prakash H Muddegowda, Sathish Babu Murugaiyan et autres

BACKGROUND \nVascular Endothelial Growth Factor (VEGF) has been implicated as a key molecule, which regulates physiological \nangiogenesis. VEGF exerts its molecular actions through Receptor Tyrosine Kinases (RTKs) VEGFR-1 and VEGFR-2, differ in \nsignaling properties. VEGF plays a vital role in embryogenesis, growth …

KEYWORDSNeovascularisation, VEGF, Diabetes Mellitus, Pre-Eclampsia, Neoplasia.

Niranjan Gopal, Srinivasan A. R, Prakash H Muddegowda, Sathish Babu Murugaiyan et autres