Bruce M. Psaty

Abstract 4354222: Deep Learning Prediction of Left Atrial Structure and Function from 12-lead Electrocardiograms

Jennifer A. Brody, Vidhushei Yogeswaran, Kerri L. Wiggins, Colleen M. Sitlani et autres

Introduction: Abnormalities in the function and structure of the left atrium, called atrial cardiopathy, are a precursor of atrial fibrillation (AF) and an important risk factor for several other cardiovascular outcomes, yet detecting abnormalities is challenging due to the cost and limited …

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Abstract 4366949: Relations Of Inflammatory Biomarkers With Incident Clinical Peripheral Artery Disease In Older Adults

Jagjot Dosanjh, Parveen K. Garg, Kenneth J. Mukamal, Mary Cushman et autres

Background: Peripheral artery disease (PAD) is a vascular condition marked by arterial narrowing that affects 8.5 million adults in the U.S. Contributions of circulating biomarkers reflecting different immune pathways have not been well established in large population-based studies of older adults. Research …

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Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals

Mengyu Zhang, Michael R. Brown, Amy R. Bentley, Thomas W. Winkler et autres

Abstract Cigarette smoking influences blood pressure (BP) levels. Studying and accounting for potential gene-smoking interactions can help discover novel loci and provide insights into biological pathways for smoking-associated BP regulation. We conducted a genome-wide association meta-analysis involving 1,188,241 individuals from 66 studies …

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Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging

Woei‐Yuh Saw, Kangjin Kim, Yichen Huang, Jeong H. Yun et autres

Mosaic loss of Y chromosome (mLOY) in blood cells is an age-related somatic mutation, but its relationship with pulmonary health remains undercharacterized. Leveraging mLOY assessment in over 12,000 men, including 5,097 from the COPDGene Study and 7,235 from six additional cohorts in …

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Association of Immune Cell Subsets With Longevity: The Cardiovascular Health Study

Petra Bůžková, Joseph A. Delaney, Nels C. Olson, Bruce M. Psaty et autres

BACKGROUND: Changes in the immune system are a potential biological mechanism of aging. We investigated the association of circulating immune cell subsets with age at death and survival to age 90. METHODS: Immune cell phenotypes were measured at baseline in 1 625 …

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Associations of circulating T-cell subsets with endothelial function: the Multi-Ethnic Study of Atherosclerosis

Theodore M. DeConne, Colleen M. Sitlani, Kevin Decker, Joseph A. Delaney et autres

Background: Endothelial dysfunction has emerged as a risk factor for many age-related diseases such as cardiovascular disease (CVD). Recently, pro-inflammatory T-lymphocytes (T-cells) have been identified as important mediators of endothelial dysfunction in multiple pre-clinical models. Pro-inflammatory and senescent T-cell subsets have also …

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Abstract P2092: The Association of Change in Circulating Biomarkers of Brain Injury with Cognitive Change and MRI Findings in the Cardiovascular Health Study

Cellas A. Hayes, Russell Tracy, W.T. Longstreth, Alison E. Fohner et autres

Background: Understanding how circulating biomarkers of brain injury correlate with cognitive function and magnetic resonance imaging. (MRI) findings of vascular brain injury is critical for developing early interventions. We aimed to elucidate the associations of change in circulating blood-based biomarkers of brain …

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Multi-ancestry genome-wide association study reveals novel genetic signals for lung function decline

Bonnie Patchen, Jingwen Zhang, Nathan Gaddis, Traci M. Bartz et autres

Abstract Rationale Accelerated decline in lung function contributes to the development of chronic respiratory disease. Despite evidence for a genetic component, few genetic associations with lung function decline have been identified. Objectives To evaluate genome-wide associations and putative downstream functionality of genetic …

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LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes

Jingzhong Ding, Anh Tram Nguyen, Kurt Lohman, Michael Taylor Hensley et autres

Associations of Serum GDF-15 Levels with Physical Performance, Mobility Disability, Cognition, Cardiovascular Disease, and Mortality in Older Adults

Katey Webber, Sheena Patel, Jorge R. Kizer, Richard Eastell et autres

Background: Growth differentiation factor 15 (GDF-15) is a member of the TGFβ superfamily secreted by many cell types and found at higher blood concentrations as chronological age increases (1). Given the emergence of GDF-15 as a key protein associated with aging, it …

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LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes

Jingzhong Ding, Anh Tram Nguyen, Kurt Lohman, Michael Taylor Hensley et autres

BACKGROUNDPreclinical studies suggest that cholesterol accumulation leads to insulin resistance. We previously reported that alterations in a monocyte cholesterol metabolism transcriptional network (CMTN) - suggestive of cellular cholesterol accumulation - were cross-sectionally associated with obesity and type 2 diabetes (T2D). Here, we …

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Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH

Josephine H. Li, Laura Brenner, Varinderpal Kaur, Katherine Figueroa et autres

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