Bonnie Patchen

Polyunsaturated Fatty Acid Associations With Epigenetic Variation in the Respiratory Epithelium

Bonnie Patchen, E Kate Phillips, Woei‐Yuh Saw, Michael Cho et autres

Multi-ancestry genome-wide association study and meta-analysis of lung function decline

Bonnie Patchen, Jingwen Zhang, Nathan Gaddis, Traci M. Bartz et autres

BACKGROUND: Despite evidence for a genetic component, few genetic associations with lung function decline have been identified. We aimed to evaluate genome-wide associations and putative downstream functionality of genetic variants for lung function decline. METHODS: We conducted genome-wide association study (GWAS) analyses …

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Additional file 1 of Multi-ancestry genome-wide association study and meta-analysis of lung function decline

Bonnie Patchen, Jingwen Zhang, Nathan Gaddis, Traci M. Bartz et autres

Supplementary Material 1.

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Multi-ancestry genome-wide association study and meta-analysis of lung function decline

Bonnie Patchen, Jingwen Zhang, Nathan Gaddis, Traci M. Bartz et autres

Abstract Background Despite evidence for a genetic component, few genetic associations with lung function decline have been identified. We aimed to evaluate genome-wide associations and putative downstream functionality of genetic variants for lung function decline. Methods We conducted genome-wide association study (GWAS) …

us, gb, kr, ca (code pays fourni par la source)

Additional file 2 of Multi-ancestry genome-wide association study and meta-analysis of lung function decline

Bonnie Patchen, Jingwen Zhang, Nathan Gaddis, Traci M. Bartz et autres

Supplementary Material 2.

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Additional file 2 of Multi-ancestry genome-wide association study and meta-analysis of lung function decline

Bonnie Patchen, Jingwen Zhang, Nathan Gaddis, Traci M. Bartz et autres

Supplementary Material 2.

us, gb, kr, ca (code pays fourni par la source)

Multi-ancestry genome-wide association study and meta-analysis of lung function decline

Bonnie Patchen, Jingwen Zhang, Nathan Gaddis, Traci M. Bartz et autres

Abstract Background Despite evidence for a genetic component, few genetic associations with lung function decline have been identified. We aimed to evaluate genome-wide associations and putative downstream functionality of genetic variants for lung function decline. Methods We conducted genome-wide association study (GWAS) …

us, gb, kr, ca (code pays fourni par la source)

Additional file 1 of Multi-ancestry genome-wide association study and meta-analysis of lung function decline

Bonnie Patchen, Jingwen Zhang, Nathan Gaddis, Traci M. Bartz et autres

Supplementary Material 1.

us, gb, kr, ca (code pays fourni par la source)

Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma

Bonnie Patchen, Cora M. Best, Jocelyn Boiteau, Beate Stokke Solvik et autres

BACKGROUND: Randomised controlled studies evaluating vitamin D supplementation in pregnancy or early childhood for preventing childhood asthma have yielded inconclusive results. Previous systematic reviews of vitamin D for asthma prevention focused on studies comparing vitamin D to placebo or studies intervening in …

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Lung Function in Pediatric Non-cystic Fibrosis Bronchiectasis Patients Compared to Cystic Fibrosis Patients: A 20-year Retrospective Cohort Study

T. Baumann, Brandon J. Hall, G. Sawicki, Ran Wang et autres

Abstract Rationale: Pediatric non-cystic fibrosis bronchiectasis (NCFB) is a heterogenous pulmonary disorder, characterized by chronic mucosal inflammation, recurrent infection, airway remodeling, and impaired mucociliary clearance. These factors contribute to a significant symptomatic burden in affected children. Despite the growing recognition of NCFB, …

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Effects of Immunomodulatory Fatty Acids on Lung Function Are Mediated Through Smoking-related Differences in DNA Methylation

Bonnie Patchen, Yu Huang, Emily Phillips, O. Rafique et autres

Abstract Rationale: Dietary polyunsaturated fatty acids (PUFAs) found in plant and seed oils and fatty fish have immunomodulatory properties that may influence lung function. Smoking impacts DNA methylation, inflammation, and lung function and may mediate the effects of PUFAs on the lungs. …

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Association Between VGDF (Vapors, Gas, Dust, Fumes) and Poverty With Lung Function Disparities Through Epigenetic Programming and Age Acceleration

Yu Huang, Bonnie Patchen, Emily Phillips, Woei‐Yuh Saw et autres

Abstract RATIONALE Occupational exposures including Vapors, Gas, Dust or Fumes (VGDF) and additional Social Determinants of Health (SDOH) may contribute to adverse respiratory outcomes, although molecular causes are understudied. DNA methylation is influenced by multiple environmental exposures and may reveal novel insights …

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