Free apical surface hetero-cellular CDH1 homophilic binding is a major mediator of blastocyst–endometrium interaction in humans
Hanzhang Ruan, Andy Chun Hang Chen, Yuxuan Xue, Kai Chuen Lee et autres
STUDY QUESTION: Is E-cadherin (CDH1) expressed on the free apical surface of endometrial epithelial cells (EECs) involved in embryo attachment? SUMMARY ANSWER: Embryonic signals induced apical expression of endometrial CDH1, which facilitated attachment via hetero-cellular CDH1 homophilic binding. WHAT IS KNOWN ALREADY: …
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