Ruppert Öllinger

Mast cells modulate macrophage biology through release of prestored CSF1

Daniel Kovacs, Klaus Heger, Piero Giansanti, Caterina Iuliano et autres

BACKGROUND: Mast cells (MCs) are tissue-resident immune cells present in connective tissues throughout the body. They exert diverse functions in immunity by rapidly releasing a plethora of preformed mediators, including proteoglycans, cytokines, and proteases, which are stored in cytoplasmic granules. OBJECTIVE: We …

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Dysregulated sphingolipid metabolism drives pancreatic carcinogenesis by interfering with Kras signalling

Ahmed Alnatsha, Ou Li, Klea Riçku, Jianying Xu et autres

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A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction

Carolin Schneider, Franziska Genevaux, Stefanie Höfer, Lukas Krauß et autres

Cancer cells must develop strategies to adapt to the dynamically changing stresses caused by intrinsic or extrinsic processes, or therapeutic agents. Metabolic adaptability is crucial to mitigate such challenges. Considering metabolism as a central node of adaptability, it is focused on an …

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