Shihui Wen

Surface dye-coordination for efficient upconversion nanosystems

Zhangqiang Li, Yun Xing, Jiajia Zhou, Guochen Bao et autres

Abstract Lanthanide-doped upconversion nanoparticles (UCNPs) exhibit distinctive optical characteristics, including excellent photostability, large anti-Stokes shifts, narrow emission bands, and tunable luminescence lifetimes. Despite their advantages, UCNPs suffer from inherently weak light absorption because of the 4f-4f transitions of lanthanide ions. Near-infrared dye-sensitization …

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Translating NIR-II imaging into clinical practice: advances and strategies

Kehong Lv, Jing Yao, Jiajia Zhou, Cuiling Zhang et autres

Near-infrared II (NIR-II) bioimaging has advanced rapidly through the development of diverse luminescent probes, improved detection hardware, and increasingly sophisticated imaging modalities. However, the translation of NIR-II imaging from preclinical demonstrations to practical biomedical use remains limited by a central challenge: probe …

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Lattice and ligand engineering for hierarchical heterogeneous nanocrystals

Rui Wang, Mengxiang Qiao, Shihui Wen, Xian Qin et autres

Precise control over the morphology, structure, and composition of nanocrystals is essential for designing advanced functional materials. Herein, we establish a general paradigm for the programmable synthesis of hierarchical heteronanocrystals by synergistically integrating ligand-mediated site-selective epitaxy with lattice mismatch engineering. We demonstrate …

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Downshifting Luminescence Rare-Earth Nanoparticles for High-Resolution In Vivo Imaging at NIR IIb/c Window

Zihang Yu, Mengfei Li, Shihui Wen, Yuezhong Xian et autres

Rare-earth nanoparticles (RENPs) operating in the NIR-IIb/c (1600–2000 nm) window hold great promise for bioimaging due to superior spatial resolution and deep tissue penetration. However, achieving high-brightness RENPs with precise emission control remains a significant challenge. Here, we report the rational design …

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Recent advances in nanomaterials for integrated phototherapy and immunotherapy

Zhuqing Sun, Nannan Wang, Yelin Wu, Shihui Wen et autres

The integration of immunotherapy with phototherapy represents a synergistic approach, combining the localized effects of nanomaterial-enabled phototherapy with systemic immune activation to achieve comprehensive therapeutic outcomes. Nanomaterials enhance light-based therapies through superior photon conversion, efficient drug delivery, and co-delivery of immune adjuvants, …

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A COVID‐19 rapid antigen test employing upconversion nanoparticles

Le Zhang, Jiajia Zhou, Olga Shimoni, Shihui Wen et autres

Abstract The COVID‐19 pandemic has underscored the critical need for rapid and accurate diagnostic tools. Current methods, including Polymerase Chain Reaction and rapid antigen tests (RAT), have limitations in speed, sensitivity, and the requirement for specialized equipment and trained personnel. Nanotechnology, particularly …

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Ultrasensitive Rapid Antigen Test by Geometric Lateral Flow Assays and Highly Doped Upconversion Nanoparticles

Le Zhang, Shihui Wen, Jawairia Umar Khan, Yuan Liu et autres

The paper-based lateral flow assay (LFA) testing strips are currently the most widely used for point-of-care testing (POCT), valued for their rapid result turnaround times in a few minutes. However, their sensitivity has been limited. Upconversion nanoparticles (UCNPs), especially highly doped ones, …

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Author Correction: Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy

Xuchen Shan, Lei Ding, Dajing Wang, Shihui Wen et autres

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A COVID-19 Rapid Antigen Test Employing Upconversion Nanoparticles

Le Zhang, Jiajia Zhou, Olga Shimoni, Shihui Wen et autres

Abstract The COVID-19 pandemic has underscored the critical need for rapid and accurate diagnostic tools. Current methods, including PCR and rapid antigen tests (RAT), have limitations in speed, sensitivity, and the requirement for specialized equipment and trained personnel. Nanotechnology, particularly upconversion nanoparticles …

au (code pays fourni par la source)

Redundancy in microbiota-mediated suppression of the soybean cyst nematode

Muzammil Hussain, Peixue Xuan, Xin Yi, Haikun Ma et autres

BACKGROUND: Soybean cyst nematodes (SCN) as animal parasites of plants are not usually interested in killing the host but are rather focused on completing their life cycle to increase population, resulting in substantial yield losses. Remarkably, some agricultural soils after long-term crop …

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Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy

Xuchen Shan, Lei Ding, Dajing Wang, Shihui Wen et autres

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Lanthanide Complex for Single-Molecule Fluorescent in Situ Hybridization and Background-Free Imaging

Fei Su, Shiyu Chen, Yuanhua Liu, Jiajia Zhou et autres

Traditional single-molecule fluorescence in situ hybridization (smFISH) methods for RNA detection often face sensitivity challenges due to the low fluorescence intensity of the probe. Also, short-lived autofluorescence complicates obtaining clear signals from tissue sections. In response, we have developed an smFISH probe …

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