Lisa M Levorse

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

Pulkit Khandelwal, Michael Tran Duong, Lisa M Levorse, Winifred Trotman et autres

INTRODUCTION: The impact of different neuropathologies on deep brain structures remains to be understood. We examine subcortical and limbic volumetry in neurodegenerative diseases involving phosphorylated tau (p-tau), α-synuclein, and transactive response DNA binding protein 43 (TDP-43). METHODS: We acquired neuropathological measures and …

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Characterizing the MRI signature of hippocampal sclerosis of aging

Gustaf Rådman, Amanda E Denning, Sadhana Ravikumar, Nicola Spotorno et autres

Abstract Background Hippocampal sclerosis of aging (HS-A), a common cause of dementia, can currently only be diagnosed at autopsy. We aimed to identify and evaluate MRI metrics to distinguish HS-A from Alzheimer’s Disease neuropathologic change (ADNC) and cases with limited/no pathology. Methods …

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Additional file 1 of Characterizing the MRI signature of hippocampal sclerosis of aging

Gustaf Rådman, Amanda E Denning, Sadhana Ravikumar, Nicola Spotorno et autres

Supplementary Material 1.

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Additional file 1 of Characterizing the MRI signature of hippocampal sclerosis of aging

Gustaf Rådman, Amanda E Denning, Sadhana Ravikumar, Nicola Spotorno et autres

Supplementary Material 1.

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Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

Pulkit Khandelwal, Michael Tran Duong, Lisa M Levorse, Winifred Trotman et autres

Introduction: The impact of different neuropathologies on deep brain structures remains to be understood. Here, we distinguish subcortical and limbic volumetry in neurodegenerative diseases involving p-tau, α-synuclein and TDP-43. Methods: We acquired neuropathological measures and brain segmentations from postmortem analysis of 132 …

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High‐resolution postmortem 7 tesla MRI yields localized atrophy measures that are more sensitive to tau pathology and neuronal loss in Alzheimer’s disease than corresponding measures on antemortem 3 tesla MRI

Pulkit Khandelwal, Michael Tran Duong, Lisa M Levorse, Sydney Lim et autres

Abstract Background Postmortem MRI has opened‐up avenues to study brain structure at ultra high‐resolution revealing details not possible to observe with in vivo MRI. Here, we present a novel package (purple‐mri) which performs tissue segmentation, anatomical parcellation and spatial normalization of postmortem …

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Associations of 18 F‐flortaucipir tau PET with quantitative tau histopathology in the medial temporal lobe

Jeffrey S. Phillips, Amanda E Denning, Lisa M Levorse, Christopher D. Brown et autres

Abstract Background 18 F‐Flortaucipir is widely used for positron emission tomography (PET) imaging of Alzheimer’s disease (AD)‐type tau, but its sensitivity in early Braak stages has been questioned, and hippocampal uptake is at least partially confounded by off‐target binding. We investigated associations …

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High‐resolution postmortem 7 tesla MRI yields localized atrophy measures that are more sensitive to tau pathology and neuronal loss in Alzheimer's disease than corresponding measures on antemortem 3 tesla MRI

Pulkit Khandelwal, Michael Tran Duong, Lisa M Levorse, Sydney Lim et autres

Abstract Background Postmortem MRI has opened‐up avenues to study brain structure at ultra high‐resolution revealing details not possible to observe with in vivo MRI. Here, we present a novel package (purple‐mri) which performs tissue segmentation, anatomical parcellation and spatial normalization of postmortem …

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Associations between Quantitative Neuronal Loss Measures and Postmortem MRI Atrophy Measures in the Human Medial Temporal Lobe in AD and LATE

Paul A. Yushkevich, Sadhana Ravikumar, Laura E.M. Wisse, Sydney Lim et autres

BACKGROUND: Medial temporal lobe (MTL) atrophy measured on MRI is a sensitive biomarker of AD-linked neurodegeneration but is not specific to AD. LATE is a common AD co-pathology that is challenging to distinguish from AD based on available validated biomarkers. LATE and …

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Associations of 18 F‐flortaucipir tau PET with quantitative tau histopathology in the medial temporal lobe

Jeffrey S. Phillips, Amanda E Denning, Lisa M Levorse, Christopher D. Brown et autres

Abstract Background 18 F‐Flortaucipir is widely used for positron emission tomography (PET) imaging of Alzheimer's disease (AD)‐type tau, but its sensitivity in early Braak stages has been questioned, and hippocampal uptake is at least partially confounded by off‐target binding. We investigated associations …

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VIOLET: Volumetric Image registration via Optimization and Learning for Efficient image Translation

Pulkit Khandelwal, Michael Tran Duong, Lisa M Levorse, Sydney Lim et autres

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Operationalizing postmortem pathology-MRI association studies in Alzheimer’s disease and related disorders with MRI-guided histology sampling

Chinmayee Athalye, Alejandra Bahena, Pulkit Khandelwal, Sheina Emrani et autres

Postmortem neuropathological examination, while the gold standard for diagnosing neurodegenerative diseases, often relies on limited regional sampling that may miss critical areas affected by Alzheimer's disease and related disorders. Ultra-high resolution postmortem MRI can help identify regions that fall outside the diagnostic …

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