Kathryn I. Alpert

Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group

Brinley N. Zabriskie, Steven G. Luke, Boris A. Gutman, Dmitry Isaev et autres

Abstract Background Schizophrenia (SCZ) is characterized by a disconnect from reality that manifests as various clinical and cognitive symptoms, and persistent neurobiological abnormalities. Sex-related differences in clinical presentation imply separate brain substrates. The present study characterized deep brain morphology using shape features …

us, de, no, es, it, ie, ca, ch, gb, ir, se (code pays fourni par la source)

Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants

Kuldeep Kumar, Claudia Modenato, Clara A. Moreau, Christopher R. K. Ching et autres

OBJECTIVE: Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) and schizophrenia. Little is known about how different CNVs conferring risk for the same condition may affect subcortical brain structures and …

ca (code pays fourni par la source)

Subcortical brain alterations in carriers of genomic copy number variants

Kuldeep Kumar, Claudia Modenato, Clara A. Moreau, Christopher R. K. Ching et autres

Objectives: Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disorders (NPDs) including autism (ASD) and schizophrenia (SZ). Overall, little is known about how different CNVs conferring risk for the same condition may affect subcortical brain …

ca, ch, fr, us, au, nl, gb, de, no (code pays fourni par la source)

A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

Boris A. Gutman, Theo G.M. van Erp, Kathryn I. Alpert, Christopher R. K. Ching et autres

Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences …

us, ru, no, gb, de, it, es, ca, ch, ie, fr, br, se, Afrique du Sud, au (code pays fourni par la source)

Deep Brain Structure Volume and Cortical Thickness Associations With Negative Symptom Domains in Schizophrenia

Theo G.M. van Erp, Paul E. Rasser, Ulrich Schall, Anton Albajes‐Eizagirre et autres

us, au, es, de, co, si, nl, it, ch (code pays fourni par la source)

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years

Sophia Frangou, Amirhossein Modabbernia, Steven Williams, Efstathios Papachristou et autres

Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In …

ca, us, gb, no, se, nl, ie, fr, es, de, it, au, br, be, Afrique du Sud (code pays fourni par la source)

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years

Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle Eve Doucet et autres

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In …

gb, us, no, se, nl, ie, fr, es, de, it, au, br, be, ca, Afrique du Sud (code pays fourni par la source)

Greater male than female variability in regional brain structure across the lifespan

Lara M. Wierenga, Gaelle Eve Doucet, Danai Dima, Ingrid Agartz et autres

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, …

Greater male than female variability in regional brain structure across the lifespan

Lara M. Wierenga, Gaelle Eve Doucet, Danai Dima, Ingrid Agartz et autres

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, …

nl, us, gb, no, se, ie, es, de, it, ch, ca, au, br, fr, Afrique du Sud, ru (code pays fourni par la source)

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

Sophia Frangou, Amirhossein Modabbernia, Gaelle Eve Doucet, Efstathios Papachristou et autres

Abstract Delineating age-related cortical trajectories in healthy individuals is critical given the association of cortical thickness with cognition and behaviour. Previous research has shown that deriving robust estimates of age-related brain morphometric changes requires large-scale studies. In response, we conducted a large-scale …

ca, us, gb, no, se, nl, ie, fr, es, de, it, au, br, at, Afrique du Sud, jp, sg (code pays fourni par la source)

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

Danai Dima, Efstathios Papachristou, Amirhossein Modabbernia, Gaelle Eve Doucet et autres

Abstract Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. …

gb, us, no, se, nl, ie, es, de, it, au, br, ca, fr, Afrique du Sud, jp, sg, ru (code pays fourni par la source)

Greater male than female variability in regional brain structure across the lifespan

Lara M. Wierenga, Gaelle Eve Doucet, Danai Dima, Ingrid Agartz et autres

Abstract For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain …

nl, us, gb, ca, no, se, ie, es, de, it, ch, au, br, fr, Afrique du Sud, ru (code pays fourni par la source)