Ian Wilmut

Contributors

Francesco Bennardo, Ming Fai Chow, Jan Frederick Engels, David S. Goodsell et autres

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Nuclear Transfer

Keith Campbell, Ian Wilmut

There are two potential roles for nuclear transfer in animal breeding. First, the production of multiple copies of elite embryos by reconstruction using embryonic blastomeres. Secondly, nuclear transfer from cultured cell populations may be used for the production of genetically modified progenitor …

Endothelial Progenitor Cells Do Not Originate From the Bone Marrow

Takeshi Fujisawa, Olga Tura-Ceide, Amanda Hunter, Andrew J. Mitchell et autres

bone marrow cells ◼ cell-and tissue-based therapy ◼ endothelial progenitor cells E ndothelial progenitor cells (EPCs) are thought to originate from the bone marrow, mobilize in response to ischemia, and home to sites of vascular injury.Despite uncertainty regarding their origin, phenotype, and …

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Cloning After Dolly

Ian Wilmut, Jane Elizabeth Taylor

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C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

Bhuvaneish Thangaraj Selvaraj, Matthew R. Livesey, Chen Zhao, Jenna M. Gregory et autres

Abstract Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis (ALS). Here, through a combination of RNA-Seq and electrophysiological studies on induced pluripotent stem cell (iPSC)-derived motor neurons (MNs), we show that increased expression of GluA1 AMPA receptor …

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Sodium channel current loss of function in induced pluripotent stem cell derived cardiomyocytes from a Brugada syndrome patient

Rebecca Martinez Moreno, Elisabet Selga Coma, Franziska Sendfeld, Norma Medina et autres

Development of an inducible platform for intercellular protein delivery

Richard Siller, Éric Dufour, Max Lycke, Ian Wilmut et autres

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Contributors

Francesco Bennardo, Ming Fai Chow, Jan Frederick Engels, David S. Goodsell et autres

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The Dolly Experiment: The First 20 Years

Ian Wilmut

Public lecture by Sir Ian Willmut who, in 1996, lead the team that cloned Dolly the sheep. Sir Ian traced the influence of early cloning innovators such as Hans Spemann, and showed how thinking about cell plasticity and reprogramming evolved over the …

Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly

Maojia Xu, Eva-Lena Stattin, Georgina Shaw, Dick K. Heinegård et autres

UNLABELLED: : Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is associated with a heterozygous mutation in the ACAN gene, resulting …

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Dolly & me

Ian Wilmut

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Cells: from Robert Hooke to cell therapy—a 350 year journey

Johan Hyllner, Chris Mason, Ian Wilmut

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