Accès ouvert
2026
article
OpenAlex
Juan Chen, Jie Yang, Bengang Huo, Mingyu Cai et autres
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a novel class of hypoglycemic agents widely used in clinical practice in recent years. Recent studies have revealed that sodium-glucose cotransporter 2 is expressed in human peritoneal mesothelial and vascular endothelial cells, suggesting its potential involvement …
cn
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Accès ouvert
2026
article
OpenAlex
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu et autres
Tissue-resident macrophages (TRMs) are long-lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological dysfunction. This review provides a comprehensive analysis of TRM biology in inflammation and cancer. We first delineate the heterogeneity and developmental …
cn
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Accès ouvert
2026
article
OpenAlex
Yuxing Wang, Zifan Zhu, Qian Wang, Xinglong Liu et autres
Escalating resistance in Pseudomonas aeruginosa (PA) underscores the need for resistance-agnostic immunotherapies. In this study, we generated a panel of 20 monoclonal antibodies against the flagellin protein FliC and identified 16G10 as a high-affinity lead. Epitope mapping revealed a conserved linear site …
cn
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Accès ouvert
2026
article
OpenAlex
Wenyi Liu, Wanda Bi, Saiying Hou, Juan Du et autres
ABSTRACT Acute lung injury (ALI) is characterized by a considerable mortality rate and currently lacks viable therapeutic strategies. Alveolar type II epithelial cells (AT2 cells) play a critical role in lung injury repair, potentially through activation of the Wnt/β‐catenin signaling cascade, which …
cn
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Accès ouvert
2025
article
OpenAlex
Fang Zhou Yu, Xiaoyue Wang, Jia Chen, Qingli Cai et autres
Abstract Background and Aims Peritoneal fibrosis (PF), a serious complication of peritoneal dialysis (PD), has limited treatment options. Recent studies show that fibroblast transdifferentiation into myofibroblasts is key in this process. Our previous research has revealed that the mesenchymal stem cell (MSC) …
cn
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Accès ouvert
2025
article
OpenAlex
Qingli Cai
This essay examines the cultural politics of Artificial Intelligence (AI) in China through the lens of postsocialism, proposing the concept of a ‘postsocialist AI’ that goes beyond the dominant paradigm of neoliberal informationalism. The essay first explores the distinct state-capital nexus in …
us
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Accès ouvert
2025
article
OpenAlex
Qiuju Han, Jiangbo Fan, Zhe Feng Xu, Wenyi Liu et autres
Sepsis is a life-threatening disease characterized by systemic inflammation and endothelial barrier dysfunction, leading to multiorgan failure and high mortality. This review provides a comprehensive overview of the pathological mechanisms underlying sepsis-induced endothelial dysfunction, focusing on glycocalyx degradation, endothelial cell death, increased …
cn, pk
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Accès ouvert
2024
article
OpenAlex
Kehong Chen, Xiaoyue Wang, Qingli Cai, Yani He et autres
Peritoneal fibrosis (PF) is a significant factor in the failure of peritoneal dialysis (PD) techniques. Recent research has shown that histone lactylation levels increase with glycolysis and intracellular lactate levels, highlighting the impact of protein lactylation in regulating chronic organ injury. In …
cn
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Accès ouvert
2024
article
OpenAlex
Mengyu Wu, Junwei Mi, Guoxin Qu, Shu Zhang et autres
Multipotent mesenchymal stem cells (MSCs) have high self-renewal and multi-lineage differentiation potentials and low immunogenicity, so they have attracted much attention in the field of regenerative medicine and have a promising clinical application. MSCs originate from the mesoderm and can differentiate not …
cn
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Accès ouvert
2024
article
OpenAlex
Mengyu Wu, Jing Liu, Shu Zhang, Yi Jian et autres
Alveolar type II (AT2) cells are key effector cells for repairing damaged lungs. Direct differentiation into AT2 cells from bone marrow mesenchymal stem cells (BMSCs) is a promising approach to treating acute lung injury (ALI). The mechanisms of BMSC differentiation into AT2 …
cn
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2023
conference-abstract
OpenAlex
Fang Yu, Xiaoyue Wang, Qingli Cai, Yani He et autres
Background: Peritoneal fibrosis (PF) is a serious clinical complication in patients undergoing long-term peritoneal dialysis (PD). Recently, histone lactylation has been found to increase with glycolysis and intracellular lactate levels, leading to chronic organ damage. Here, we investigated the role and mechanism …
cn
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Accès ouvert
2023
article
OpenAlex
Fang Zhou Yu, Jia Chen, Xiaoyue Wang, Qingli Cai et autres
Abstract Background and Aims Peritoneal dialysis (PD) as a long-term renal replacement therapy is limited by peritoneal fibrosis. The purpose of our study was to identify the mechanism of mesenchymal stem cell-derived exosomes (MSC-Exos) in regulating the transdifferentiation of fibroblasts (FBs) to …
cn
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