Junwei Mi

Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation

Mengyu Wu, Junwei Mi, Guoxin Qu, Shu Zhang et autres

Multipotent mesenchymal stem cells (MSCs) have high self-renewal and multi-lineage differentiation potentials and low immunogenicity, so they have attracted much attention in the field of regenerative medicine and have a promising clinical application. MSCs originate from the mesoderm and can differentiate not …

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Shh Signaling from the Injured Lung Microenvironment Drives BMSCs Differentiation into Alveolar Type II Cells for Acute Lung Injury Treatment in Mice

Mengyu Wu, Jing Liu, Shu Zhang, Yi Jian et autres

Alveolar type II (AT2) cells are key effector cells for repairing damaged lungs. Direct differentiation into AT2 cells from bone marrow mesenchymal stem cells (BMSCs) is a promising approach to treating acute lung injury (ALI). The mechanisms of BMSC differentiation into AT2 …

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Endothelial–mesenchymal transition as a novel mechanism for generating myofibroblasts during wound healing and scarring

Ling Jun Guo, Junwei Mi, Huacai Zhang, Jie Gao et autres

BACKGROUND: The endothelial-mesenchymal transition (EndMT) is an important mechanism in tissue regeneration and the development of organ fibrosis. Whether EndMT occurs in wound healing and scarring remains unknown. MATERIALS AND METHODS: The isolated cells from the normal dermal tissue and the wound …

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Optimal H2O2 preconditioning to improve bone marrow mesenchymal stem cells’ engraftment in wound healing

Ling Jun Guo, Juan Du, Dan-feng Yuan, Zhang Ya et autres

Abstract Background The transplantation of bone marrow mesenchymal stem cells (BMSCs) is a promising therapeutic strategy for wound healing. However, the poor migration capacity and low survival rate of transplanted BMSCs in wounds weaken their potential application. Objective To identify the optimal …

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Biomimetic collagen biomaterial induces in situ lung regeneration by forming functional alveolar

Linjie Wang, Yannan Zhao, Feng Yang, Meng Feng et autres

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Lung endothelial cell-targeted peptide-guided bFGF promotes the regeneration after radiation induced lung injury

Dongwei Guan, Junwei Mi, Xi Chen, Yonghui Wu et autres

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Transdermal Vascular Endothelial Growth Factor Delivery with Surface Engineered Gold Nanoparticles

Ying Ian Chen, Yonghui Wu, Jining Gao, Zihao Zhang et autres

Skin injuries caused by burns or radiation remain a serious concern in terms of clinical therapy. Because of the damage to the epidermis or dermis, angiogenesis is needed to repair the skin. Vascular endothelial growth factor (VEGF) is one of the most …

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