Accès ouvert
2025
article
OpenAlex
Eizo Marutani, Maria Islaine Portela de Miranda, Timothy Durham, Sharon H. Kim et autres
Parkinson's disease (PD) is characterized by inclusions of α-synuclein (α-syn) and mitochondrial dysfunction in dopaminergic (DA) neurons of the substantia nigra pars compacta (SNpc). Patients with PD anecdotally experience symptom improvement at high altitude; chronic hypoxia prevents the development of Leigh-like brain …
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Accès ouvert
2025
article
OpenAlex
Lindy Williams, Sharon H. Kim, Yanling Li, Saida Heshmati et autres
Feeling and expressing love in daily life are interconnected and perhaps mutually influential experiences. In this study we examined the reciprocal dynamics of feeling and expressing love and its relation to well-being using an ecological momentary assessment design. Over a four-week period, …
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Accès ouvert
2025
preprint
OpenAlex
Daisy V Zavala, Sharon H. Kim, John Michael Felt, Zita Oravecz et autres
Background and Objectives: Positive epigenetic age acceleration, in which a person’s biological age is older than their chronological age, is associated with worse cognitive performance. Most findings, however, rely on cross-sectional lab-administered measures of cognition or longitudinal average scores that collapse the …
Accès ouvert
2025
preprint
OpenAlex
Daisy V Zavala, Sharon H. Kim, John Michael Felt, Zita Oravecz et autres
Background and Objectives: Positive epigenetic age acceleration, in which a person’s biological age is older than their chronological age, is associated with worse cognitive performance. Most findings, however, rely on cross-sectional lab-administered measures of cognition or longitudinal average scores that collapse the …
us
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Accès ouvert
2025
article
OpenAlex
Zita Oravecz, Martin J. Sliwinski, Sharon H. Kim, Lindy Williams et autres
Abstract Repeated assessments of cognitive performance yield rich data from which we can extract markers of cognitive performance. Computational cognitive process models are often fit to repeated cognitive assessments to quantify individual differences in terms of substantively meaningful cognitive markers and link …
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2025
article
OpenAlex
Zita Oravecz, Joachim Vandekerckhove, Jonathan George Hakun, Sharon H. Kim et autres
OBJECTIVES: Cognitive change is a complex phenomenon encompassing both retest-related performance gains and potential cognitive decline. Disentangling these dynamics is necessary for effective tracking of subtle cognitive change and risk factors for Alzheimer's Disease and Related Dementias (ADRD). METHOD: We applied a …
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Accès ouvert
2024
preprint
OpenAlex
Lindy Williams, Sharon H. Kim, Yanling Li, Saida Heshmati et autres
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Accès ouvert
2023
conference-abstract
OpenAlex
Sharon H. Kim, Yanling Li, Karra Harrington, Jonathan George Hakun et autres
Abstract With an aging population, understanding cognitive aging is essential for developing interventions to support independence and well-being. Additionally, there is a need for sensitive measures that can differentiate subtle cognitive decline related to neurodegenerative disease from age-related changes. In particular, Alzheimer’s …
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Accès ouvert
2023
article
OpenAlex
Saeideh Heshmati, Nermin Kıbrıslıoğlu Uysal, Sharon H. Kim, Zita Oravecz et autres
Abstract PERMA is a multidimensional framework that explains well-being through five hedonic and eudaimonic psychological elements–Positive emotions, Engagement, Relationships, Meaning, Accomplishment. Soon after the PERMA framework was proposed, PERMA-Profiler was introduced as a validated assessment tool for measuring these five elements of …
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Accès ouvert
2021
article
OpenAlex
Yuchen Zhang, Rui Guo, Sharon H. Kim, Hardik Shah et autres
The recently identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. How this novel beta-coronavirus virus, and coronaviruses more generally, alter cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs …
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Accès ouvert
2020
article
OpenAlex
Sneha P. Rath, Rohit Sharma, Rahul Gupta, Tslil Ast et autres
The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA). We previously developed MitoCarta, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome. This …
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Accès ouvert
2019
article
OpenAlex
Tsz‐Leung To, Alejandro M. Cuadros, Hardik Shah, Wendy H.W. Hung et autres
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