Carlos A. Garcia

The rpf/DSF signalling system of Stenotrophomonas maltophilia positively regulates biofilm formation, production of virulence-associated factors and β-lactamase induction

Eliana Alcaraz, Carlos A. Garcia, Laura E. Friedman, Beatriz Passerini de Rossi

Stenotrophomonas maltophilia is a multidrug-resistant opportunistic pathogen. S. maltophilia quorum-sensing system is mediated by the diffusible signal factor (DSF), which synthesis depends on rpfF. It has been reported that rpfF disruption in S. maltophilia K279a leads to a loss of DSF synthesis, …

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A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion

Carlos A. Garcia, Anaïs Burgain, Julien Chaillot, Émilie Pic et autres

A poorly exploited paradigm in the antimicrobial therapy field is to target virulence traits for drug development. In contrast to target-focused approaches, antivirulence phenotypic screens enable identification of bioactive molecules that induce a desirable biological readout without making a priori assumption about …

ca (code pays fourni par la source)

A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion

Carlos A. Garcia, Anaïs Burgain, Julien Chaillot, Émilie Pic et autres

Abstract A poorly exploited paradigm in the antimicrobial therapy field is to target virulence traits for drug development. In contrast to target-focused approaches, antivirulence phenotypic screens enable identification of bioactive molecules that induce a desirable biological readout without making a priori assumption …

ca (code pays fourni par la source)

Stenotrophomonas maltophilia isolated from patients exposed to invasive devices in a university hospital in Argentina: molecular typing, susceptibility and detection of potential virulence factors

Eliana Alcaraz, Carlos A. Garcia, Mariana Papalia, Carlos Alberto Vay et autres

Purpose. The aim of this work was to investigate the presence of selected potential virulence factors, susceptibility and clonal relatedness among 63 Stenotrophomonas maltophilia isolates recovered from patients exposed to invasive devices in a university hospital in Argentina between January 2004 and …

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The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway

Carlos A. Garcia, Faïza Tebbji, Michelle C. Daigneault, Ning-Ning Liu et autres

Candida albicans is a natural component of the human microbiota but also an opportunistic pathogen that causes life-threatening infections. The human gastrointestinal tract is the main reservoir of C. albicans , from where systemic infections originate as a consequence of the disruption …

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pH-Dependant Antifungal Activity of Valproic Acid against the Human Fungal Pathogen Candida albicans

Julien Chaillot, Faïza Tebbji, Carlos A. Garcia, Hugo Würtele et autres

Current antifungal drugs suffer from limitations including toxicity, the emergence of resistance and decreased efficacy at low pH that are typical of human vaginal surfaces. Here, we have shown that the antipsychotic drug valproic acid (VPA) exhibited a strong antifungal activity against …

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Stenotrophomonas maltophilia interferes via the DSF-mediated quorum sensing system with Candida albicans filamentation and its planktonic and biofilm modes of growth

Beatriz Passerini de Ross, Carlos A. Garcia, Eliana Alcaraz, Mirta A. Franco

Stenotrophomonas maltophilia is a nosocomial pathogen of increasing importance. S. maltophilia K279a genome encodes a diffusible signal factor (DSF) dependent quorum sensing (QS) system that was first identified in Xanthomonas campestris pv. campestris . DSF from X. campestris is a homologue of …

Stenotrophomonas maltophilia interferes via the DSF-mediated quorum sensing system with Candida albicans filamentation and its planktonic and biofilm modes of growth

Beatriz Passerini de Rossi, Carlos A. Garcia, Eliana Alcaraz, Mirta A. Franco

Stenotrophomonas maltophilia is a nosocomial pathogen of increasing importance. S. maltophilia K279a genome encodes a diffusible signal factor (DSF) dependent quorum sensing (QS) system that was first identified in Xanthomonas campestris pv. campestris. DSF from X. campestris is a homologue of farnesoic …

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Modulatory antimicrobial activity of Piper arboretum extracts (Zingiberaceae)

Saulo Relison Tintino, Celestina Elba Sobral de Souza, Gláucia M.M. Guedes, Jaqueline I. V. Costa et autres

The side effects of certain antibiotics have been a recent dilemma in the medical arena. Due this fact, the necessity of natural product discovery could provide important indications against several pharmacological targets and combat many infectious agents. Piper arboreum Aub. (Piperaceae) has …

Modulatory antimicrobial activity of piper arboreum extracts

Saulo Relison Tintino, Celestina Elba Sobral de Souza, Gláucia M.M. Guedes, Jaqueline I. V. Costa et autres

Abstract The side effects of certain antibiotics have been a recent dilemma in the medical arena. Due this fact, the necessity of natural product discovery could provide important indications against several pharmacological targets and combat many infectious agents. Piper arboreum Aub. (Piperaceae) …

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Siderophores of Stenotrophomonas maltophilia: detection and determination of their chemical nature.

Carlos A. Garcia, Beatriz Passerini de Rossi, Eliana Alcaraz, Carlos Alberto Vay et autres

Stenotrophomonas maltophilia is an emerging nosocomial pathogen. Despite the broad spectrum of syndromes associated with S. maltophilia infections, little is known about its virulence factors, including siderophore production. The aims of this work were to detect S. maltophilia siderophores and to determine …

ar (code pays fourni par la source)

Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus

Thomas E. Kehl‐Fie, Seth Chitayat, M. Indriati Hood, Steven M. Damo et autres

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