Michelle C. Daigneault

Correction: Analysis of early childhood intestinal microbial dynamics in a continuous-flow bioreactor

Alessandra Granato, Simone Renwick, Christopher Yau, Tiffany Kong et autres

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Analysis of early childhood intestinal microbial dynamics in a continuous-flow bioreactor

Alessandra Granato, Simone Renwick, Christopher Yau, Tiffany Kong et autres

BACKGROUND: The human gut microbiota is inoculated at birth and undergoes a process of assembly and diversification during the first few years of life. Studies in mice and humans have revealed associations between the early-life gut microbiome and future susceptibility to immune …

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Bacterial lipopolysaccharide modulates immune response in the colorectal tumor microenvironment

Arielle Kae Sulit, Michelle C. Daigneault, Emma Allen‐Vercoe, Olin Silander et autres

Immune responses can have opposing effects in colorectal cancer (CRC), the balance of which may determine whether a cancer regresses, progresses, or potentially metastasizes. These effects are evident in CRC consensus molecular subtypes (CMS) where both CMS1 and CMS4 contain immune infiltrates …

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Holtiella tumoricola gen. nov. sp. nov., isolated from a human clinical sample

Emma Allen‐Vercoe, Michelle C. Daigneault, Sarah J. Vancuren, Kyla Cochrane et autres

The diversity of bacteria associated with biopsy material obtained from patients with colorectal cancer was investigated using culture techniques. A novel bacterium, strain CC70AT, was isolated by diluting a sample of homogenized tissue in anaerobic medium, and then plating to yield a …

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The Robogut: A Bioreactor Model of the Human Colon for Evaluation of Gut Microbial Community Ecology and Function

Connor Gianetto-Hill, Sarah J. Vancuren, Brendan A. Daisley, Simone Renwick et autres

The human colon is inhabited by a complex community of microbes. These microbes are integral to host health and physiology. Understanding how and when the microbiome causally influences host health will require microbiome models that can be tightly controlled and manipulated. While …

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Enterohemorrhagic Escherichia coli responds to gut microbiota metabolites by altering metabolism and activating stress responses

Stefanie Vogt, Antonio Serapio-Palacios, Sarah E. Woodward, Andrew S. Santos et autres

Enterohemorrhagic Escherichia coli (EHEC) is a major cause of severe bloody diarrhea, with potentially lethal complications, such as hemolytic uremic syndrome. In humans, EHEC colonizes the colon, which is also home to a diverse community of trillions of microbes known as the …

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Bacterial lipopolysaccharide modulates immune response in the colorectal tumor microenvironment

Arielle Kae Sulit, Michelle C. Daigneault, Emma Allen‐Vercoe, Olin Silander et autres

Abstract Immune responses can have opposing effects in colorectal cancer (CRC), the balance of which may determine whether a cancer regresses, progresses, or potentially metastasizes. These effects are evident in CRC consensus molecular subtypes (CMS) where both CMS1 and CMS4 contain immune …

nz, ca (code pays fourni par la source)

Effects of Antibiotic Pretreatment of an Ulcerative Colitis-Derived Fecal Microbial Community on the Integration of Therapeutic Bacteria In Vitro

Kaitlyn Oliphant, Kyla Cochrane, Kathleen Schroeter, Michelle C. Daigneault et autres

Patients with gastrointestinal disorders often exhibit derangements in their gut microbiota, which can exacerbate their symptoms. Replenishing these ecosystems with beneficial bacteria through fecal microbiota transplantation is thus a proposedly useful therapeutic; however, clinical success has varied, necessitating research into strategies to …

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Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children

Alexandra Paun, Christopher Yau, Shahab Meshkibaf, Michelle C. Daigneault et autres

genotype and islet autoantibody specificity and with a future diagnosis of T1D. Further, we present a platform to investigate antibacterial antibodies in biological fluids that is applicable to studies of autoimmune diseases and responses to therapeutic interventions.

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Effects of defined gut microbial ecosystem components on virulence determinants of Clostridioides difficile

Christian Carlucci, Carys S. Jones, Kaitlyn Oliphant, Sandi Yen et autres

Many cases of Clostridioides difficile infection (CDI) are poorly responsive to standard antibiotic treatment strategies, and often patients suffer from recurrent infections characterized by severe diarrhea. Our group previously reported the successful cure of two patients with recurrent CDI using a standardized …

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The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway

Carlos A. Garcia, Faïza Tebbji, Michelle C. Daigneault, Ning-Ning Liu et autres

Candida albicans is a natural component of the human microbiota but also an opportunistic pathogen that causes life-threatening infections. The human gastrointestinal tract is the main reservoir of C. albicans , from where systemic infections originate as a consequence of the disruption …

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Towards standards for human fecal sample processing in metagenomic studies

Paul Igor Costea, Georg Zeller, Shinichi Sunagawa, Eric D. Pelletier et autres

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