Michelle Jung

The black fly salivary protein Simukunin inhibits complement activation through the lectin pathway protease MASP-2

Michelle Jung, Molly E. Ring, Brian Bonilla, Sundar Ganesan et autres

Salivary secretions from blood-feeding arthropods are enriched with bioactive molecules that counteract host hemostatic and immune defenses, including blood coagulation, platelet aggregation, complement activation, and vasoconstriction. Although numerous salivary components have been identified and functionally characterized across hematophagous arthropods, their specific roles …

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Global Analysis of Aggregation Determinants in Small Protein Domains

Cydney M. Martell, Kamil K. Gebis, Han My Van, Y. Gutierrez et autres

Protein aggregation is an obstacle for engineering effective recombinant proteins for biotechnology and therapeutic applications. Predicting protein aggregation propensity remains challenging due to the complex interplay of sequence, structure, environmental factors, and external stress conditions, particularly for globular proteins. To understand the …

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Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs

S. Mori, Dhrubajyoti Datta, Lydia A. Perkins, Michelle Jung et autres

Unlocked nucleic acid (UNA) is a nucleic acid analog that has an acyclic ribose ring lacking the bond between C2' and C3' atoms. The base-pairing properties of UNA have been studied, and it has been used as a scaffold for conjugation, but …

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The Effects of Cyproheptadine on Severe COVID-19 From the I-SPY COVID Adaptive Platform Trial

Sara C. Auld, Jeremy R. Beitler, Paul Berger, Ellen L. Burnham et autres

Background Severe COVID-19 has been associated with hypercoagulability and platelet activation, which is known to result in excessive accumulation of serotonin. However, few studies have evaluated whether serotonergic blockade may improve clinical outcomes among those with COVID-19. Research Question Does cyproheptadine, an …

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One-Year Outcomes After Decision Aid-Led Tapering of Advanced Therapy in Rheumatoid Arthritis

Glen Hazlewood, Michelle Jung, Elżbieta Kamińska, Nick Bansback et autres

Objectives The Canadian Rheumatology Association clinical practice guidelines recommend offering tapering of advanced therapy to people with rheumatoid arthritis (RA) who are in sustained remission and provide a decision aid to support these discussions. Our goal was to understand the impact of …

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Appointments by Choice: An Implementation Pilot Study for Patient-Initiated Follow-Up Care in Rheumatoid Arthritis

Manuel Ester, Kiran Dhiman, Ann Rebutoc, Alexandra Charlton et autres

Objectives The aim of the study was to conduct an implementation pilot for Appointments by Choice (ABC), a new patient-initiated follow-up model seeking to optimize follow-up efficiency and patient-centeredness of rheumatoid arthritis (RA) care. Objectives were to evaluate patient recruitment and early …

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A theory of change for patient-initiated follow-up care in rheumatoid arthritis

Manuel Ester, Krista A. White, Kiran Dhiman, Saania Zafar et autres

BACKGROUND: Timely, high-quality care is critical to rheumatoid arthritis (RA) management. In Alberta, thousands of individuals with RA are waiting for care due to the resource-intensive nature of lifelong follow-ups and rheumatologist shortages. With 20-50% of routine follow-ups not leading to treatment …

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Non-criteria antiphospholipid antibody profiles and thrombotic outcomes in a cohort of patients with systemic lupus erythematosus

Alistair Murray, Eric J. Campbell, Ann E. Clarke, Megan R.W. Barber et autres

OBJECTIVES: Antiphospholipid syndrome (APS) is characterised by the presence of antiphospholipid antibodies (aPLs) and clinical outcomes of thrombosis and/or obstetric morbidity and is associated with systemic lupus erythematosus (SLE). IgG antiphosphatidylserine/prothrombin complex (aPS/PT), IgM aPS/PT and IgG anti-beta 2 glycoprotein 1-domain 1 …

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Decision Aid–Led Tapering of Biologic and Targeted Synthetic Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis: A Qualitative Study

Jungyeon Lee, Claire Barber, Michelle Jung, Elżbieta Kamińska et autres

OBJECTIVE: To explore the experiences and perspectives of patients and rheumatologists on decision aid (DA)-led tapering of advanced therapy in rheumatoid arthritis (RA). METHODS: Semistructured interviews were completed with patients and rheumatologists, embedded within a pilot study of DA-led tapering (ie, dose …

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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Kirk Brown, Jayaprakash K. Nair, Maja M. Janas, Yesseinia Angleró-Rodríguez et autres

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Burn Injury-Induced Extracellular Vesicle Production and Characteristics

Xiaoyuan Yang, Victor Chatterjee, Ethan Zheng, Amanda J. Reynolds et autres

ABSTRACT: Extracellular vesicles (EVs) are nano-sized membrane-bound particles containing biologically active cargo molecules. The production and molecular composition of EVs reflect the physiological state of parent cells, and once released into the circulation, they exert pleiotropic functions via transferring cargo contents. Thus, …

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Cytokine autoantibodies in SARS-CoV-2 prepandemic and intrapandemic samples from an SLE cohort

May Y. Choi, Ann E. Clarke, Katherine A Buhler, Michelle Jung et autres

Cytokine autoantibodies, particularly those directed to type I interferon (T1IFN), have been reported to portend an increased risk of severe COVID-19. Since SLE is one of the conditions historically associated with T1IFN autoantibodies, we sought to determine the prevalence of cytokine autoantibodies …

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