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Alissa Sayer, Guang Yang, Ethan Zheng, Hui Shen
Fractures of the hand and/or forearm account for 1.5% of all emergency department visits, with children aged 5 to 14 years accounting for 26% of these fractures.Percutaneously inserted wires (K-wires) are frequently used in the treatment of hand bone fractures.K-wires are inexpensive, …
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Xiaoyuan Yang, Ethan Zheng, Xiaoqi Sun, Amanda J. Reynolds et autres
ABSTRACT: Severe burns are associated with massive tissue destruction and cell death where nucleus histones and other damage-associated molecular patterns are released into the circulation and contribute to the pathogenesis of multiple-organ dysfunction. Currently, there is limited information regarding the pathophysiology of …
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Xiaoyuan Yang, Ethan Zheng, Victor Chatterjee, Yonggang Ma et autres
Abstract Extracellular vesicles (EVs) are bioactive membrane‐encapsulated particles generated by a series of events involving membrane budding, fission and fusion. Palmitoylation, mediated by DHHC palmitoyl acyltransferases, is a lipidation reaction that increases protein lipophilicity and membrane localization. Here, we report palmitoylation as …
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Xiaoyuan Yang, Victor Chatterjee, Ethan Zheng, Amanda J. Reynolds et autres
ABSTRACT: Extracellular vesicles (EVs) are nano-sized membrane-bound particles containing biologically active cargo molecules. The production and molecular composition of EVs reflect the physiological state of parent cells, and once released into the circulation, they exert pleiotropic functions via transferring cargo contents. Thus, …
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Xiaoyuan Yang, Ethan Zheng, Yonggang Ma, Victor Chatterjee et autres
Abstract Renal dysfunction is one of the most common complications of septic injury. One critical contributor to septic injury-induced renal dysfunction is renal vascular dysfunction. Protein palmitoylation serves as a novel regulator of vascular function. Here, we examined whether palmitoyl acyltransferase (PAT)-DHHC21 …
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Xiaoyuan Yang, Victor Chatterjee, Ethan Zheng, Yonggang Ma et autres
DHHC21 belongs to a family of palmitoyl acyltransferases (PATs) and catalyzes the addition of palmitic acid to cysteine residue(s) of a protein. This reversible posttranslational modification dynamically controls protein localization and function, thus regulating various cellular processes. Extracellular vesicles (EVs) are membrane‐encapsulated …
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Xiaoyuan Yang, Ethan Zheng, Yonggang Ma, Victor Chatterjee et autres
Abstract Renal dysfunction is one of the most common complications of septic injury. One critical contributor to septic injury-induced renal dysfunction is renal vascular dysfunction. Protein palmitoylation serves as a novel regulator of vascular function. Here, we examined whether palmitoyl acyltransferase (PAT)-DHHC21 …
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Xiaoyuan Yang, Victor Chatterjee, Yonggang Ma, Ethan Zheng et autres
Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent attachment of palmitate is reversibly and dynamically regulated by two opposing sets of enzymes: palmitoyl acyltransferases containing a zinc finger aspartate-histidine-histidine-cysteine …
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Xiaoyuan Yang, Ethan Zheng, Victor Chatterjee, Alexandria Creasy et autres
Palmitoylation is a reaction of 16‐carbon palmitic acid attachment to a cysteine residue of a protein via thioester linkage, catalyzed by a family of palmitoyl acyltransferases containing the DHHC motif. This post‐translational modification plays a critical role in regulating protein function, subcellular …
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Victor Chatterjee, Xiaoyuan Yang, Byeong Cha, Alexandria Creasy et autres
Extracellular vesicles (EVs) are a heterogenous population of sub‐micron sized vesicles released by cells during physiological or pathological stimulation. Circulating vesicles not only serve as important diagnostic/prognostic biomarkers, but also interact with blood or vascular cells and regulate multiple cellular processes by …
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Xiaoyuan Yang, Victor Chatterjee, Alexandria Creasy, Ethan Zheng et autres
Extracellular vesicles (EVs) are membrane‐encapsulated particles released from various types of cells, ranging from 30–1000 nm in diameter. EVs facilitate intercellular communication by transferring proteins and lipid among cells not in direct contact. Recent studies suggest the involvement of EVs in the …
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