Patrick R. Hannon

An environmentally relevant phthalate mixture impairs ovulatory prostaglandin and progesterone receptor pathways in human granulosa cells in vitro

Katie L Land, Hong Xu, James W. Akin, Patrick R. Hannon

• Phthalate mixture decreases ovulatory P4, PGR , and PG levels in human granulosa cells. • Reduced P4 levels were due to decreases in P4 steroidogenic proteins and enzymes. • Reduced PGR levels were due to decreases in cAMP/PKA and ERK1/2 levels …

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The inhibition of prostaglandin production during ovulation by exposure to a phthalate mixture is circumvented by cAMP analogue supplementation in a human granulosa cell model

Patrick R. Hannon, Katie L Land, Hong Xu, James W. Akin et autres

ABSTRACT Exposure to individual phthalates disrupts ovarian function; however, the direct effects of phthalate mixture exposure on ovulation is unknown, especially in women. Human granulosa cells were used to test the hypothesis that exposure to a phthalate mixture (PHTmix; derived from women’s …

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Bayesian benchmark dose modeling analysis and derivation of points of departure for female reproductive toxicity following exposure to di(2-ethylhexyl) phthalate (DEHP) — effects on reproductive hormones, folliculogenesis and estrous cyclicity

Antero Vieira Silva, Ilari Tarvainen, Mattias Öberg, Mary J. Laws et autres

Endocrine-disrupting chemicals such as di(2-ethylhexyl) phthalate (DEHP) pose significant risks to human reproductive health. However, regulatory frameworks often lack sufficient data on sensitive female-specific reproductive endpoints. This study investigates the sensitivity of hypothalamic-pituitary-ovarian (HPO) axis endpoints to DEHP exposure in adult female …

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IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Phthalates disrupt female reproductive health: a call for enhanced investigation into mixtures

Katie L Land, Sundus Ghuneim, Patrick R. Hannon

In brief: Exposure to phthalates, known endocrine-disrupting chemicals (EDCs), is ubiquitous, but the effects on women's reproductive health are largely unknown. This review summarizes the literature investigating associations between phthalate exposures and clinical reproductive outcomes and reproductive disease states in women, and …

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Targeting Female Reproductive Function During Follicular Maturation, Ovulation, and Fertilization: Critical Windows for Pharmaceutical or Toxicant Action

Patrick R. Hannon, Ulrike Luderer

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Protease expression in the human and rat cumulus–oocyte complex during the periovulatory period: a role in cumulus–oocyte complex migration

Ketan Shrestha, Muraly Puttabyatappa, Michelle A.A. Wynn, Patrick R. Hannon et autres

The migratory and matrix-invading capacities of the cumulus-oocyte complex have been shown to be important for the ovulatory process. In metastatic cancers, these capacities are due to increased expression of proteases, however, there is limited information on protease expression in the cumulus-oocyte …

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Intricate Regulation of Folliculogenesis in the Ovary

Misung Jo, So‐Youn Kim, Jacqueline Southall, Patrick R. Hannon et autres

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Ovulation

Patrick R. Hannon

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Bayesian Benchmark Dose Modeling Analysis and Derivation of Points of Departure for Female Reproductive Toxicity Following Exposure to Di(2-Ethylhexyl) Phthalate (Dehp) − Effects on Reproductive Hormones, Folliculogenesis and Estrous Cyclicity

Antero Vieira Silva, Ilari Tarvainen, Mattias Öberg, Mary J. Laws et autres

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Exposure to a phthalate mixture disrupts ovulatory progesterone receptor signaling in human granulosa cells in vitro

Patrick R. Hannon, James W. Akin, Thomas E. Curry

Exposure to phthalates disrupts ovarian function. However, limited studies have investigated the effects of phthalate mixtures on ovulation, especially in women. Human granulosa cells were used to test the hypothesis that exposure to a phthalate mixture (PHTmix) disrupts progesterone (P4)/progesterone receptor (PGR) …

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Conscience, Law, and Politics

Patrick R. Hannon

Of the many questions on which our title invites reflection, one in particular has again achieved prominence in the United States: how is a politician who is Roman Catholic expected to vote when a measure purports to legalise what church teaching says …

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The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

Katie L Land, Frances G. Miller, Ava C. Fugate, Patrick R. Hannon

Exposure to endocrine-disrupting chemicals (EDCs) is unavoidable, which represents a public health concern given the ability of EDCs to target the ovary. However, there is a large gap in the knowledge about the impact of EDCs on ovarian function, including the process …

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