Ulrike Luderer

Effects of microgravity on human physiology

Ben Cools, M. Smith, Pierre Boutouyrie, Valerio Ciccone et autres

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Irradiation with a mixed heavy ion beam induces ovarian follicle loss and dose-dependent mixed ovarian tumor development

Kathleen N. Leon Parada, Gregory Lawson, Polly Y. Chang, Eleanor A. Blakely et autres

Over 25% of active NASA astronauts are women who will be exposed to low daily doses and dose rates of galactic cosmic rays (GCR) in space. We hypothesized that exposing mice to a preliminary simulated GCR mixed heavy ion beam composed of …

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Adolescent exposure to Δ9-tetrahydrocannabinol impairs testicular function in young adult male mice

Jinhwan Lim, Caitlin Quach, Julie Nguyen, Samantha Getze et autres

Cannabis use typically starts in early to mid-adolescence. Δ9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, targets cannabinoid receptors (CBRs) to exert its pharmacological effects. Expression of CBRs has been observed in human and rodent testes, but their potential role in the …

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Contributors

Ginika Agwu, S. Akyuz, Lana Almukhtar, Joshua S. Alwood et autres

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Ovarian issues in human spaceflight

Kathleen Leon Parada, Ulrike Luderer

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IMPACT OF REAL-LIFE ENVIRONMENTAL EXPROSURES ON REPRODUCTION: Adverse impacts of particulate matter air pollution on female and male reproduction

Ulrike Luderer

In brief: Particulate matter (PM) air pollution contains many chemicals that are individually known to have adverse effects on reproduction, as well as numerous others that have not been investigated for effects on reproduction. This review discusses the scientific literature investigating the …

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Decreased glutathione synthesis in granulosa cells, but not oocytes, of growing follicles decreases fertility in mice

Rachel Cinco, Kelli F. Malott, Jinhwan Lim, Laura Velasco Ortíz et autres

Prior studies showed that mice deficient in the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in synthesis of the thiol antioxidant glutathione, have decreased ovarian glutathione concentrations, chronic ovarian oxidative stress, poor oocyte quality resulting in early preimplantation embryonic …

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Targeting Female Reproductive Function During Follicular Maturation, Ovulation, and Fertilization: Critical Windows for Pharmaceutical or Toxicant Action

Patrick R. Hannon, Ulrike Luderer

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Ovarian Toxicity of Polycyclic Aromatic Hydrocarbons

Ulrike Luderer

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Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally

Jinhwan Lim, Toshi Shioda, Kelli F. Malott, Keiko Shioda et autres

People are widely exposed to polycyclic aromatic hydrocarbons, like benzo[a]pyrene (BaP). Prior studies showed that prenatal exposure to BaP depletes germ cells in ovaries, causing earlier onset of ovarian senescence post-natally; developing testes were affected at higher doses than ovaries. Our primary …

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Supplementary Figure 1 from Glutathione-Deficient Mice Have Increased Sensitivity to Transplacental Benzo[a]pyrene-Induced Premature Ovarian Failure and Ovarian Tumorigenesis

Jinhwan Lim, Gregory Lawson, Brooke Nakamura, Laura Ortiz et autres

PDF file - 9.7MB, Hematoxylin and eosin stained sections of ovarian tumors in Gclm+/+ and Gclm-/- F1 females prenatally exposed to BaP

Supplementary Figure 1 from Glutathione-Deficient Mice Have Increased Sensitivity to Transplacental Benzo[a]pyrene-Induced Premature Ovarian Failure and Ovarian Tumorigenesis

Jinhwan Lim, Gregory Lawson, Brooke Nakamura, Laura Ortiz et autres

PDF file - 9.7MB, Hematoxylin and eosin stained sections of ovarian tumors in Gclm+/+ and Gclm-/- F1 females prenatally exposed to BaP