Michael Erdmann

From manual to semi-automatic semantic annotation: about ontology-based text annotation tools

Michael Erdmann, Alexander Maedche, Hans-Peter Schnurr, Steffen Staab

Semantic Annotation is a basic technology for intelli- gent content and is beneficial in a wide range of content- oriented intelligent applications. In this paper we present our work in ontology-based semantic annotation, which is embedded in a scenario of a knowledge …

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A computational SOX10 network-based selection strategy to identify new drug targets in uveal melanoma

Anja Wessely, Christopher Lischer, Adrian Weich, Claudia Kammerbauer et autres

Abstract Uveal melanoma (UM) is the most common intraocular malignancy in adults. In contrast to cutaneous melanoma (CM), effective treatment options for metastatic UM are limited. The transcription factor SOX10 is crucial for CM initiation and survival, making it an interesting candidate …

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An artificial intelligence model of whole-slide pathology specimens differentiating cutaneous high-grade squamous proliferations

Anne Petzold, Anja Wessely, Michael Erdmann, Stefan Schliep et autres

Cutaneous squamous cell carcinoma (cSCC) and verruca vulgaris (VV) are skin conditions involving the proliferation of epidermal keratinocytes requiring fundamentally different treatments. Histological evaluation of highly differentiated squamous cell proliferations can be challenging, particularly in small or superficial samples. This study aims …

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Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME , CDC7 and Ki67

Elias A. T. Koch, Ramona Erber, Michael Erdmann, Markus V. Heppt et autres

Abstract Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target for melanoma immunotherapy, but its expression in benign melanocytic lesions and its diagnostic value remain unexplored. This study assessed CSPG4 expression in benign nevi (BN), dysplastic nevi (DN), and superficial spreading melanomas …

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Implementation of an open chemistry knowledge base with a Semantic Wiki

Charlotte Neidiger, Tarek Saier, Kai Kühn, Victor Larignon et autres

Abstract In this work, a concept for an open chemistry knowledge base was developed to integrate chemical research results into a collaboratively usable platform. To achieve this, we enhanced Semantic MediaWiki (SMW) to support the collection and structured summary of chemical data …

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Metastasiertes ekkrines Porokarzinom bei einem jungen Patienten

Rafaela Kramer, Abbas Agaimy, Carola Berking, Michael Erdmann

Zusammenfassung Ein 26-jähriger Patient mit ekkrinem Porokarzinom entwickelte regionäre Lymphknotenmetastasen. Anhand der vom Alter und Verlauf ungewöhnlichen Konstellation dieses metastasierten Adnexkarzinoms stellen wir das Management in der Primärversorgung, Durchuntersuchung, Nachsorge und Therapie bei Rezidiv vor. Die Behandlung seltener Adnexkarzinome wie des ekkrinen …

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Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or adenoid cystic carcinoma

Thomas Eigentler, Ioannis Thomas, Igor Samoylenko, Michael Erdmann et autres

BACKGROUND: CV8102, a toll-like receptor 7/8 and RIG I agonist, has demonstrated antitumor immune responses in preclinical studies. We investigated intratumoral (IT) administration of CV8102 in patients with anti-programmed cell death protein-1 (PD-1) therapy-naïve or anti-PD-1 therapy-refractory cutaneous melanoma (cMEL) and in …

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Metastasiertes ekkrines Porokarzinom bei einem jungen Patienten

Rafaela Kramer, Abbas Agaimy, Carola Berking, Michael Erdmann

Zusammenfassung Ein 26-jähriger Patient mit ekkrinem Porokarzinom entwickelte regionäre Lymphknotenmetastasen. Anhand der vom Alter und Verlauf ungewöhnlichen Konstellation dieses metastasierten Adnexkarzinoms stellen wir das Management in der Primärversorgung, Durchuntersuchung, Nachsorge und Therapie bei Rezidiv vor. Die Behandlung seltener Adnexkarzinome wie des ekkrinen …

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Brief Communication: Treatment Outcomes for Advanced Melanoma of Unknown Primary Compared With Melanoma With Known Primary

Oana‐Diana Persa, J.C. Hassel, Theresa Steeb, Michael Erdmann et autres

SUMMARY: Most patients with advanced melanomas have a known primary site [melanoma of known primary (MKP)]. However, 2%-9% of patients are diagnosed with melanoma metastasis of unknown primary (MUP). As MUP and MKP have similar UV-induced mutations and molecular signatures, it is …

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Gleichzeitiges Auftreten zweier malignomverdächtiger Hautveränderungen

Matthias D. Kaufmann, Michael Erdmann, Stefan Schliep, Caroline Voskens et autres

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Implementation of an Open Chemistry Knowledge Base with a Semantic Wiki

Charlotte Neidiger, Tarek Saier, Kai Kühn, Victor Larignon et autres

In this work, a concept for an open chemistry knowledge base was developed to integrate chemical research results into a collaboratively usable platform. To achieve this, we enhanced Semantic MediaWiki (SMW) to support the collection and structured summary of chemical data contained …

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Patients’ and dermatologists’ preferences in artificial intelligence–driven skin cancer diagnostics: A prospective multicentric survey study

Sarah Haggenmüller, Roman C. Maron, Achim Hekler, Eva Krieghoff‐Henning et autres

To the Editor: Artificial intelligence (AI) has shown promise for improving diagnostics of skin cancer by matching or surpassing experienced clinicians.1 However, the successful clinical application depends on acceptance by patients and dermatologists. In this prospective multicentric survey study with a response …

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