Sunwen Chou

The Fourth International Consensus Guidelines on the Management of Cytomegalovirus in Solid Organ Transplantation

Camille N. Kotton, Deepali Kumar, Sunwen Chou, Randall T. Hayden et autres

Abstract visual presentation is available at https://journals.lww.com/transplantjournal/fulltext/2025/07000/the_fourth_international_consensus_guidelines_on.6.aspx

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Dynamics and Evolution of Donor-derived Cytomegalovirus Infection in 3 Solid Organ Transplant Recipients With the Same Multiorgan Donor

Fien Horsten, Sunwen Chou, Sarah Gillemot, Yves Debaveye et autres

BACKGROUND: Cytomegalovirus (CMV) infection poses a significant risk to immunosuppressed transplant recipients, manifesting through primary infection, reinfection, or reactivation. METHODS: We analyzed the emergence of drug resistance in CMV infection in 3 patients who were later found to have received an allograft …

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Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum

Per Ljungman, Roy F. Chemaly, Fareed Khawaya, Sophie Alain et autres

Cytomegalovirus (CMV) infection and disease are important causes of morbidity and mortality in transplant recipients. For the purpose of developing consistent reporting of CMV outcomes in clinical trials, definitions of CMV infection and disease were developed and most recently published in 2017. …

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Phenotypes of cytomegalovirus genetic variants encountered in a letermovir clinical trial illustrate the importance of genotyping validation

Sunwen Chou

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Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants

Sunwen Chou, J Watanabe

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Use of next-generation sequencing to detect mutations associated with antiviral drug resistance in cytomegalovirus

Nicholas Streck, Mark J. Espy, Matthew J. Ferber, Eric W. Klee et autres

ABSTRACT Cytomegalovirus (CMV) is a significant cause of morbidity and mortality among immunocompromised hosts, including transplant recipients. Antiviral prophylaxis or treatment is used to reduce the incidence of CMV disease in this patient population; however, there is concern about increasing antiviral resistance. …

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Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients

Sunwen Chou, Sophie Alain, Carlos Cervera, Roy F. Chemaly et autres

BACKGROUND: This drug resistance analysis of a randomized trial includes 234 patients receiving maribavir and 116 receiving investigator-assigned standard therapy (IAT), where 56% and 24%, respectively, cleared cytomegalovirus DNA at week 8 (treatment responders). METHODS: Baseline and posttreatment plasma samples were tested …

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Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H

Martin Schütz, Regina Müller, Eileen Socher, Christina Wangen et autres

The complex host interaction network of human cytomegalovirus (HCMV) involves the regulatory protein kinase pUL97, which represents a viral cyclin-dependent kinase (CDK) ortholog. pUL97 interacts with the three human cyclin types T1, H, and B1, whereby the binding region of cyclin T1 …

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Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing

Sunwen Chou, Steven B. Kleiboeker

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Highly conserved interaction profiles between clinically relevant mutants of the cytomegalovirus CDK-like kinase pUL97 and human cyclins: functional significance of cyclin H

Martin Schütz, Regina Müller, Eileen Socher, Christina Wangen et autres

Abstract The complex network of host interaction of the human cytomegalovirus (HCMV) involves the regulatory protein kinase pUL97, which represents a viral cyclin-dependent kinase (CDK) ortholog. pUL97 interacts with the three human cyclin types T1, H and B1, whereby the binding region …

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Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility

Sunwen Chou

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Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing

Sunwen Chou, Matthew Watters, Rohita Sinha, Steven B. Kleiboeker

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