Patrick J. Gallagher

Pomalidomide downregulates FIZ1 to induce fetal hemoglobin in adult erythroid progenitors

Marion Serra, Zachary Hyman, Ryan J. Ashley, Brian M. Dulmovits et autres

Abstract Reactivation of fetal hemoglobin (HbF) expression has been a target for the treatment of hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia for several decades. While gene therapy has recently been approved as a cure for these hemoglobinopathies, its high …

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Barriers and perceptions of WHONET/BacLink adoption in Nepal: A qualitative study of clinical microbiology laboratories

Sanju Maharjan, Patrick J. Gallagher, Manish Gautam, Sanjay Gautam et autres

BACKGROUND: The International Vaccine Institute-led CAPTURA (Capturing Data on Antimicrobial Resistance Patterns and Trends in Use in Regions of Asia) project delivered capacity building activities to strengthen antimicrobial resistance surveillance activities in Nepal. METHODS: The CAPTURA project trained 97 laboratory personnel from …

np, us, kr, au, gb, Madagascar, de (code pays fourni par la source)

The Postmortem Pathology of Sudden Death in Chronic Alcohol Exposure and Acute Alcohol Intoxication

Harry R. Haynes, Patrick J. Gallagher, Maria Thom, R Morovat et autres

ABSTRACT: Chronic alcohol exposure is common in all societies and is seen at high rates during coronial (medicolegal) postmortem examinations. In both setting of acute alcohol intoxication and chronic misuse, a wide range of pathologies and mechanisms of death may be encountered, …

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Recording and Reporting of Antimicrobial Resistance (AMR) Priority Variables and Its Implication on Expanding Surveillance Sites in Nepal: A CAPTURA Experience

Sanju Maharjan, Patrick J. Gallagher, Manish Kumar Gautam, Hea Sun Joh et autres

Data on antimicrobial resistance (AMR) from sites not participating in the National AMR surveillance network, conducted by National Public Health Laboratory (NPHL), remain largely unknown in Nepal. The "Capturing Data on Antimicrobial Resistance Patterns and Trends in Use in Regions of Asia" …

kr, us, np, Madagascar, de, gb (code pays fourni par la source)

Autopsies after Surgery and Percutaneous Interventions

Megan H. Jenkins, Patrick J. Gallagher, Russell J. Delaney

Deaths occurring during or after a surgical procedure are commonly encountered by autopsy pathologists. The examinations may be complex and technically challenging. Most deaths are as a result of predictable natural disease, although in a small number there may be issues related …

Significant ketoacidosis at autopsy: a single-centre systematic review

Paida Gwiti, Fiona Davidson, Peter Beresford, Patrick J. Gallagher

AIM: To examine the value of vitreous beta-hydroxybutyrate and serum acetone in the investigation of sudden unexpected death. METHODS: Coroners' autopsy reports from a provincial UK city, with a population of approximately 900 000, over a 24-month period with significant ketoacidosis were …

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The congenital dyserythropoieitic anemias: genetics and pathophysiology

Richard A. King, Patrick J. Gallagher, Rami N. Khoriaty

Purpose of review The congenital dyserythropoietic anemias (CDA) are hereditary disorders characterized by ineffective erythropoiesis. This review evaluates newly developed CDA disease models, the latest advances in understanding the pathogenesis of the CDAs, and recently identified CDA genes. Recent findings Mice exhibiting …

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Fatal acute hepatic failure secondary to thrombotic portal venopathy after commencing abemaciclib and fulvestrant treatment for advanced breast carcinoma: a unique autopsy finding

Harry R. Haynes, Vivek Mohan, Behrang Mozayani, Patrick J. Gallagher

We present an autopsy case of hepatic thrombotic portal venopathy resulting in decompensated liver failure and death which occurred rapidly after commencing abemaciclib and fulvestrant chemotherapy for advanced invasive lobular carcinoma of the breast. The diagnosis was confirmed histologically. This is the …

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Autopsy examination in sudden cardiac death: a current perspective on behalf of the Association for European Cardiovascular Pathology

Jytte Banner, Cristina Basso, Zoe Tolkien, Ivana Kholová et autres

In sudden cardiac death, an autopsy is an essential step in establishing a diagnosis of inherited cardiac disease and identifying families that require cardiac screening. To evaluate aspects of post-mortem practice in Europe, a questionnaire was designed and circulated to both clinical …

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Skills you may need to acquire or refine.

Ashleigh Gallagher, Patrick J. Gallagher

Other transferable skills you probably have and how to talk about them.

Ashleigh Gallagher, Patrick J. Gallagher

Five transferable skills you definitely have and how to talk about them.

Ashleigh Gallagher, Patrick J. Gallagher