Significant ketoacidosis at autopsy: a single-centre systematic review
Rattachement africain : gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
AIM: To examine the value of vitreous beta-hydroxybutyrate and serum acetone in the investigation of sudden unexpected death. METHODS: Coroners' autopsy reports from a provincial UK city, with a population of approximately 900 000, over a 24-month period with significant ketoacidosis were studied. Demographic features, medical history, anatomical and histological findings, and biochemical parameters, including renal function, vitreous glucose, serum and vitreous alcohol, were analysed. RESULTS: Forty-two cases (28 males and 14 females) were identified; 55% had a history of alcohol and/or substance misuse, and mental health problems, particularly depression and anxiety, and 16% were diabetic. In all, 50% of subjects had alcoholic ketoacidosis (AKA), 19% had diabetic ketoacidosis (DKA) and 12% had a history of both diabetes and alcohol abuse. In 19% of cases, an exact cause of ketoacidosis was established. In AKA, the subjects typically had low vitreous glucose and low or undetected blood alcohol levels. All of the subjects with raised vitreous glucose levels had DKA. CONCLUSION: Ketoacidosis is relatively common and should be considered as a cause of sudden death, especially in alcoholic patients and patients with diabetes with no clear cause of death at autopsy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Significant ketoacidosis at autopsy: a single-centre systematic review
- Date Crossref
- 03/01/2022
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Peterborough City Hospital pays non établi dans la noticeÉtablissement de santé
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Southmead Hospital pays non établi dans la noticeÉtablissement de santé
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University of Bristol Department of Medical Education pays non établi dans la noticeUniversité ou école supérieure
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North West Anglia NHS Foundation Trust Department of Histopathology pays non établi dans la noticeOrganisation à but non lucratif
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Department of Clinical Biochemistry pays non établi dans la noticeÉtablissement de santé
Peterborough City Hospital, Southmead Hospital et Department of Medical Education — University of Bristol, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.