Hiroyuki Kojima

Induction of Melanin Synthesis by Pueraria lobata Leaves in B16 Murine Melanoma Cells and Three-Dimensional Human Skin Equivalent

Takuhiro Uto, Tomoe Ohta, Mana Kairada, Jin Yoshitomi et autres

Puerariae Radix, the root of Pueraria lobata (Willd.) Ohwi is primarily used as a traditional herbal medicine in East Asia. Although phytochemical and biological investigations of the roots have been well-reported, those of the leaves are limited. To explore the potential value …

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The efficacy of 3D hologram support with mixed-reality technique in pancreatobiliary endoscopy

Kazumasa Nagai, maki sugimoto, Takao Itoi, Hirohito Minami et autres

Background and Aims: Mixed-reality (MR) technology is an advanced holographic imaging system that uses wearable devices to display three-dimensional (3D) images in clinical environments. In pancreatobiliary endoscopy, MR technology can facilitate 3D visualization of the bile and pancreatic ducts, enhancing spatial awareness …

Associations between urinary phthalate metabolites and reproductive, adrenal, and gonadotropic hormones in peripubertal children: the Hokkaido study

Ayaka Yasuda, Yu Ait Bamai, Takeshi Yamaguchi, Rahel Mesfin Ketema et autres

Phthalates have raised concerns regarding the disruption of hormone synthesis and signaling. The purpose of this study was to investigate the associations between urinary phthalate metabolites and 18 hormones, including reproductive, adrenal, and gonadotropic hormones, in peripubertal children. The study comprised a …

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Artemisia capillaris with two novel active compounds, Kawarayomogin I and II, inhibits HYBID (KIAA1199) expression as well as hyaluronic acid degradation

Kazal Boron Biswas, Yuka Kawai, Satoshi Nakagawa, Kyoko Kanai et autres

Hyaluronic acid (HA) is an important component of the skin's extracellular matrix, and its degradation leads to wrinkles. Hyaluronan-binding protein involved in hyaluronan depolymerization (HYBID) is the main factor responsible for HA degradation in dermis. This study aimed to identify natural plant …

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Comparative study on gene expression profiles in the liver of male neonatal mice prenatally exposed to PFOA and its alternative HFPO-DA

Wataru Murase, Atsuhito Kubota, Ryo Hakota, Ayaka Yasuda et autres

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Phthalate Metabolites in Urine and Their Associations with Sex and Steroid Hormones in Peripubertal Children: The Hokkaido Study

Ayaka Yasuda, Yu Ait Bamai, Takeshi Yamaguchi, Rahel Mesfin Ketema et autres

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Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells

Ayaka Yasuda, Wataru Murase, Atsuhito Kubota, Naoto Uramaru et autres

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Immunoregulatory Effects of Elemental Diet and Its Ingredient, Tryptophan, via Activation of the Aryl Hydrocarbon Receptor in Mice

Atsuhito Kubota, Shungo Imai, Ryoichi Aoyagi, Wataru Murase et autres

Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation and its treatment varies widely; however, when inflammation is high, a complete nutrient containing pre-digested elemental diet (ED) is used to preserve the intestinal tract. In this study, we investigated the mechanisms …

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Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays

Wataru Murase, Atsuhito Kubota, Atsuko Araki, Masaru Terasaki et autres

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Fucoxanthinol Promotes Apoptosis in MCF-7 and MDA-MB-231 Cells by Attenuating Laminins–Integrins Axis

Ayaka Yasuda, Momoka Wagatsuma, Wataru Murase, Atsuhito Kubota et autres

Fucoxanthinol (FxOH), the main metabolite of the marine carotenoid fucoxanthin, exerts anti-cancer effects. However, fragmentary information is available on the growth-inhibiting effects of FxOH on breast cancer (BC). We investigated the growth-inhibiting effects of FxOH on human BC cells (MCF-7 and MDA-MB-231 …

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A Biscuit Containing Fucoxanthin Prevents Colorectal Carcinogenesis in Mice

Masaru Terasaki, Wataru Murase, Yukino Kamakura, Serina Kawakami et autres

Fucoxanthin (Fx) is a critical pigment required for photosynthesis in brown algae and microalgae. Fx is also a dietary marine carotenoid that with potent anticancer activity in vitro and in vivo. Some popular light meals for increased satiety, such as biscuits, cereals, …

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Effects of benzotriazole UV stabilizers, UV-PS and UV-P, on the differentiation of splenic regulatory T cells via aryl hydrocarbon receptor

Atsuhito Kubota, Masaru Terasaki, Yuuta Sakuragi, Ryuta Muromoto et autres

Benzotriazole UV stabilizers (BUVSs) are widely used as additives in various materials, including plastics, to prevent damage from UV-irradiation. However, despite the extensive usage of BUVSs, information on their toxicological properties is limited. In this study, we investigated the effect of BUVSs …

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