Associations between urinary phthalate metabolites and reproductive, adrenal, and gonadotropic hormones in peripubertal children: the Hokkaido study
Rattachement africain : jp, be. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Phthalates have raised concerns regarding the disruption of hormone synthesis and signaling. The purpose of this study was to investigate the associations between urinary phthalate metabolites and 18 hormones, including reproductive, adrenal, and gonadotropic hormones, in peripubertal children. The study comprised a cross-sectional analysis of participants in the Hokkaido Birth Cohort Study. We collected data from 429 school children aged 9–12 living in Sapporo, Japan. Ten phthalate metabolites and 14 steroid hormones were analyzed using LC-MS/MS, whereas four peptide hormones were detected using immunoassays. Multivariable linear regression, quantile-based g-computation (qg-computation), and Bayesian kernel machine regression (BKMR) were used to investigate the associations between the individual phthalate metabolites and the phthalate mixtures with hormone levels, as well as with puberty based on hormone levels. In girls, we found that higher phthalate metabolite levels, as well as phthalate mixtures, were significantly associated with lower dehydroepiandrostenedione-sulfate (DHEA-S) and higher (androstenedione + testosterone)/DHEA-S. The higher phthalate mixture showed lower levels of LH, FSH, and cortisol levels among girls, whereas higher 11-deoxycortisol levels. In boys, a higher phthalates mixture was significantly associated with a higher estradiol/testosterone ratio, whereas lower levels of insulin-like factor-3 (INSL3), testosterone, (androstenedione + testosterone)/DHEA-S, testosterone/androstenedione, and cortisol/cortisone. Higher phthalate mixtures were associated with lower prevalence of puberty in girls. These findings indicate that phthalate exposure may disrupt the hormones in children during puberty. • Phthalate metabolites and hormones were measured in peripubertal children. • DHEA-S in girls was inversely related to phthalate metabolites and their mixture. • In boys, the estradiol/testosterone was positively linked to a phthalate mixture. • Phthalates mixture exposure was linked to a lower prevalence of puberty in girls. • DEHP metabolites had the greatest impact on hormone level fluctuation.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Associations between urinary phthalate metabolites and reproductive, adrenal, and gonadotropic hormones in peripubertal children: the Hokkaido study
- Date Crossref
- 01/07/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hokkaido University of Science Center for Environmental and Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Health Sciences University of Hokkaido pays non établi dans la noticeUniversité ou école supérieure
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Sapporo University pays non établi dans la noticeUniversité ou école supérieure
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Hokkaido University pays non établi dans la noticeUniversité ou école supérieure
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University of Antwerp Toxicological Center pays non établi dans la noticeUniversité ou école supérieure
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Hokkaido University Hospital pays non établi dans la noticeÉtablissement de santé
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National Center For Child Health and Development pays non établi dans la noticeOrganisme public
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Asahikawa Medical University pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Pharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Department of Molecular Endocrinology pays non établi dans la noticeInstitution
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
Center for Environmental and Health Sciences — Hokkaido University of Science, Health Sciences University of Hokkaido et Sapporo University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.