Tomoe Ohta

Amyloid-β aggregation inhibitory activity and neuroprotective effects of metabolites of Trichoderma pluripenicillatum

Hayato Yoshikawa, Takahiro Matsumoto, Emi Yoshida, Tomoe Ohta et autres

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Prenylflavonoids with antiallergic activity from the roots of Sophora flavescens Aiton

Shogo Nishikawa, Ryuya Takada, Mahiro Nagabuchi, Ayana Nagano et autres

A methanol extract of the roots of Sophora flavescens Aiton, which is used as a crude drug Sophora Root ( Sophorae Radix ; " Kujin " in Japanese) and is listed in the Japanese Pharmacopoeia XIX, exerted antiallergic effects on ear passive …

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β-glucuronidase inhibitors isolated from the fruit of Forsythia suspensa (Thunb.) Vahl

Shogo Nishikawa, Ryuya Takada, Yusuke Shimomoto, Sara Morishita et autres

A methanol extract from the fruit of Forsythia suspensa (Thunb.) Vahl (Oleaceae), which is used as the crude drug Forsythiae Fructus ( Forsythia Fruit ; “ Rengyo ” in Japanese) and is listed in the Japanese Pharmacopoeia XIX, exerted enzymatic β-glucuronidase inhibitory …

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Development of karapinchamine A-related carbazoles with antiproliferative activity against glioblastoma-derived cancer stem cells and blood–brain barrier permeability

Haruka Kawatake, Sakura Ichioka, Yutaro Ohki, Kouta Ugawa et autres

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Constituents with dipeptidyl peptidase-IV inhibitory effect from the flower buds of Rosa rugosa

Seikou Nakamura, Takahiro Matsumoto, Rie Yasui, Toshiki Minamide et autres

Seven hydrolysable tannins, rugosin A (1), rugosin C (2), rugosin A methyl ester (3), casuarictin (4), tellimagrandin II (5), 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (6), and 1,3-di-O-galloyl-4,6-O-hexahydroxydiphenoyl-β-D-glucopyranose (7) were isolated from the flower buds of Rosa rugosa. Among these constituents, compounds 1, 2, 3, 5, and …

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Three new terpenoids from the fruit peels of Citrus Hassaku Yu.Tanaka

Daisuke Imahori, Takuya Muraoka, Tomoe Ohta, Tatsusada Yoshida et autres

Citrus hassaku Yu. Tanaka is a relatively less-known species within the genus. In this study, we aimed to isolate novel compounds from this species, elucidate their chemical structures via spectroscopic and physicochemical analyses, and evaluate their antiproliferative effects using the WST-8 assay. …

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Girinimbine produced in Bergera koenigii callus cultures with antiproliferative activity against glioblastoma stem cells

Tomoe Ohta, Tomomi Shun, Kouta Ugawa, Junko Tsukioka et autres

Callus cultures derived from medicinal plants offer useful platforms for producing valuable secondary metabolites. We established a callus culture system from Bergera koenigii leaves and examined the effects of phytohormone composition on callus growth and carbazole alkaloid accumulation. To the best of …

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Qualitative and quantitative analyses, and biological activities of major anthraquinones in Rubia argyi and R. tinctorum

Tomoe Ohta, Junko Tsukioka, Shota Miyanowaki, Souichi Nakashima et autres

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Antiproliferative activity against glioblastoma-derived cancer stem cells and blood–brain-barrier permeability of carbazole derivatives from Murraya plants and related synthetic compounds

Kouta Ugawa, Kaori Yajima, Tomoe Ohta, Seikou Nakamura

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Induction of Melanin Synthesis by Pueraria lobata Leaves in B16 Murine Melanoma Cells and Three-Dimensional Human Skin Equivalent

Takuhiro Uto, Tomoe Ohta, Mana Kairada, Jin Yoshitomi et autres

Puerariae Radix, the root of Pueraria lobata (Willd.) Ohwi is primarily used as a traditional herbal medicine in East Asia. Although phytochemical and biological investigations of the roots have been well-reported, those of the leaves are limited. To explore the potential value …

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The Yeast‐Fermented Garlic and a Balance of Spermine/Spermidine Activates Autophagy via EGR1 Transcriptional Factor

Kun Xie, Satoshi Yano, Jinyun Wang, Shota Yamakoshi et autres

Spermine (SPM) and spermidine (SPD) are polyamines found in all organisms, and their concentrations can be regulated by ingestion. We demonstrated that yeast-fermented garlic (YF) extract significantly increased autophag flux in OUMS-36T-1 and HeLa cells expressing the fluorescent probe (GFP-LC3-RFP-LC3ΔG). YF-induced increase …

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Antioxidant and Anti-glycation Properties of Rehmannia glutinosa Leaves

Tomoe Ohta, Takahiro Kitagawa, Hiroki Tashiro, Takuhiro Uto

The root of Rehmannia glutinosa is an ingredient in herbal medicine used for tonifying blood in Japanese Kampo medicine and traditional Chinese medicine. Biological investigations of the roots have been well reported; however, those of the leaves are limited. In this study, …

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