Hao Chen

Route of Allergen Immunotherapy: A Global Look Into Physicians' Motivations

Carmen Vidal, Davide Caimmi, Pablo Rodríguez del Río, Óscar Lado‐Baleato et autres

BACKGROUND: Current Allergen Immunotherapy (AIT) guidelines provide no definitive guidance on route selection, whether subcutaneous (SCIT) or sublingual (SLIT). The primary objective of this study was to characterize real-world AIT prescription patterns, with emphasis on route selection, using a factor analysis approach …

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First Report of Macrophomina phaseolina Causing Root Rot on Pogostemon cablin in China

Zhongyue Sun, Hao Chen, Jielan Guo, Junjie Song et autres

Patchouli (Pogostemon cablin (Blanco) Benth.) is an important medicinal plant belonging to the family Lamiaceae, which is native to South and Southeast Asia. It is renowned for its detoxification, antibacterial and other pharmacological properties (Pan et al. 2024), and is widely used …

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Real-World Assessment of Dupilumab in Chinese Atopic Dermatitis Patients: Efficacy, Safety, and Impact of Comorbidities

Hao Chen, Nan Huang, Wenjing Li, Yaqi Yang et autres

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease often accompanied by comorbidities such as allergic rhinitis (AR) and asthma. Dupilumab, a monoclonal antibody targeting IL-4Rα, has demonstrated significant efficacy and safety in the treatment of AD. However, its effectiveness in …

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Association of Outdoor Allergens with Respiratory Allergic Diseases: A Systematic Review

Hao Chen, Shuangmei Ye, Qing Jiang, Yaqi Yang et autres

INTRODUCTION: The global burden of respiratory allergic diseases linked to outdoor allergens remains poorly quantified despite increasing evidence of the allergens' impacts on respiratory allergic diseases. This systematic review synthesizes epidemiological evidence on the association between exposure to outdoor airborne allergens and …

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Efficacy of House Dust Mite Immunotherapy in Chinese Allergic Rhinitis Patients With Diverse Sensitization Patterns: A Multicenter Study ( COVER Study)

Qingxiu Xu, Xuan Yuan, Wang Liao, Hao Chen et autres

BACKGROUND: Allergen immunotherapy (AIT) is the only etiological treatment for allergic rhinitis (AR) patients, yet the impact of allergen sensitization patterns on AIT efficacy remains unclear. This study aimed to assess the effectiveness of subcutaneous immunotherapy (SCIT) using a native house dust …

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Development and Validation of a Risk Prediction Model for Mild Cognitive Impairment in Older Chinese Adults with Chronic Diseases

Yuanyuan Peng, Entong Ren, Hao Chen, Ya‐Nan Ou et autres

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Development and validation of a predictive model for frailty risk in older adults with cardiovascular-metabolic comorbidities

Entong Ren, Yuanyuan Peng, Hao Chen, Weihua Li

Background With the rapid progression of population aging, the number of frail individuals is steadily rising, making frailty a pressing public health issue that demands urgent attention. Compared to individuals with a single cardiovascular-metabolic disease, patients with cardiovascular-metabolic multimorbidity (CMM) are more …

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Restoration of IFN ‐γ‐Producing MAIT Cell Correlates to Beneficial Allergen Immunotherapy in Allergic Rhinitis Patients

Ying Jiang, Xin Wang, Qing Jiang, Hao Chen et autres

BACKGROUND: Mucosal-associated invariant T cells (MAIT) are emerging as important regulators at mucosal surfaces. While these cells have been linked to a Th1-biased immune response and support for B cells, their roles in allergic diseases characterised by type 2 inflammation remain elusive. …

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Hereditary Angioedema ( HAE ) in China: Advancing Awareness, Access, Advocacy and Alliances From the Greater Bay Area to the Global HAE Community

Philip H. Li, Jinxian Huang, C. Wang, Jane C. Y. Wong et autres

The article offers an overview of the progress in managing Hereditary Angioedema (HAE) in China, with a specific focus on the Greater Bay Area (GBA). Through the '4As' framework-Awareness, Access, Advocacy and Alliance-the article explores the challenges and advancements in HAE care. …

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Allergen immunotherapy and dupilumab in atopic dermatitis: Clinical efficacy and disparities in immunological indicators

Liu Jin, Lin Yang, Qingxiu Xu, Qing Jiang et autres

Objective Allergen immunotherapy (AIT) and dupilumab have been confirmed to improve symptoms of atopic dermatitis (AD); however, the precise immune mechanisms underlying their efficacy and whether they can elicit synergistic immune effects remain not fully elucidated. We aimed to investigate the clinical …

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Advancements in understanding anaphylaxis: From triggers to therapeutic strategies

Le Li, Hao Chen

Anaphylaxis is a complex and dynamic condition, marked by a heterogeneity of triggers, pathophysiological pathways, and clinical presentations. Although IgE-mediated immune responses are the predominant drivers of anaphylaxis, non-IgE-mediated mechanisms, including complement activation, engagement of the contact system, and IgG-mediated processes, also …

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The value of fixed segment mobility in posterior dynamic stabilization: a single-center retrospective study

Yulu Sun, Jianbin Guan, Hao Chen, Xiaojie Sun et autres

PURPOSE: This study aims to compare the effects of two generations of the Isobar dynamic fixation system-Isobar TTL (first-generation, less mobile) and Isobar EVO (second-generation, more mobile)-on the surgical and adjacent intervertebral disc segments, based on MRI findings. METHODS: A retrospective analysis …

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