Jennifer Dawson

Enhancing Public Health Strategies: Addressing the RSV Burden in Alabama Through Clinical Treatment, Community Prevention, and Surveillance Approaches

Martha K. Findley Roper, Jennifer Dawson

Introduction: Respiratory Syncytial Virus (RSV) is a highly contagious pathogen driving morbidity, hospitalizations, and economic burden. This review uses the epidemiological triad and National Wastewater Surveillance System data to assess transmission, viral load spikes in Alabama, and strategies for treatment and prevention. …

us (code pays fourni par la source)

Just the facts: diagnosis and acute management of pediatric concussion

Spencer Cho, Jennifer Dawson, Roger Leonard Zemek

ca (code pays fourni par la source)

Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima H. Abbas, Kaja Abbas et autres

BACKGROUND: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital …

Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima H. Abbas, Jonathan Raihan Abbas et autres

BACKGROUND: Molnupiravir and nirmatrelvir-ritonavir are oral antivirals that have shown efficacy in preventing disease progression in outpatients with COVID-19. We aimed to evaluate these treatments for patients hospitalised with COVID-19 pneumonia, for whom data on these antivirals are scarce. METHODS: The RECOVERY …

TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada

Roger Leonard Zemek, Lisa M. Albrecht, Sharon E Johnston, John J. Leddy et autres

INTRODUCTION: Concussion affects over 400 000 Canadians annually, with a range of causes and impacts on health-related quality of life. Research to date has disproportionately focused on athletes, military personnel and level I trauma centre patients, and may not be applicable to …

ca, us, hk (code pays fourni par la source)

Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima H. Abbas, Jaffar Abbas et autres

Background: Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients. We have previously reported that higher dose corticosteroids cause harm in patients with clinical hypoxia but not receiving ventilatory support (the combination of non-invasive …

A MICROFLUIDIC CHOLINE SENSING SYSTEM TO DETECT ORGANOPHOSPHORUS POISONING BY THE CONTINUOUS MEASUREMENT OF CHANGES IN ACETYLCHOLINESTERASE ACTIVITY

Georgia Smith, Nick Coe, Jennifer Dawson, Thomas E. Mann et autres

gb, au (code pays fourni par la source)

Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial

Saul N. Faust, Richard Haynes, Christine Elizabeth Jones, Natalie Staplin et autres

BACKGROUND: Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess the effect of intravenous immunoglobulin or corticosteroids compared with …

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Accelerated immune ageing is associated with COVID-19 disease severity

Janet M. Lord, Tonny Veenith, Jack Sullivan, Archana Sharma‐Oates et autres

Abstract Background The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and acute disease severity, we determined the immune phenotype of …

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Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury

Maxime Taquet, Zuzanna Skórniewska, Henrik Zetterberg, John Geddes et autres

A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury …

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Clinical Practice Guideline Recommendations in Pediatric Mild Traumatic Brain Injury: A Systematic Review

Lynne Moore, Anis Ben Abdeljelil, Pier‐Alexandre Tardif, Roger Leonard Zemek et autres

ca (code pays fourni par la source)

Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study

Omer Elneima, Hamish J. C. McAuley, Olivia C. Leavy, James Duncan Chalmers et autres

The Post-Hospitalisation COVID-19 (PHOSP-COVID) study is a national UK multicentre cohort study of patients who were hospitalized for COVID-19 and subsequently discharged. PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitalization, understand the underlying mechanisms of …

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