Accès ouvert déclaré 2025 article

TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada

Roger Leonard Zemek, Lisa M. Albrecht, Sharon E Johnston, John J. Leddy, Andrée‐Anne Ledoux, Nick P. Reed, Noah D. Silverberg, Keith Owen Yeates, Monica Lamoureux, Charlotte M. Anderson, Nicholas James Barrowman, Miriam H. Beauchamp, Kitty Y.A. Chen, Araba F. Chintoh, Achelle Cortel‐LeBlanc, Miguel Cortel-LeBlanc, Daniel J. Corwin, Stephanie Cowle, Kristine Dalton, Jennifer Dawson, Andrew B. Dodd, Khaled El Emam, Carolyn A. Emery, Erin E. Fox, Pamela Fuselli, Isabelle J Gagnon, Christopher C. Giza, Steven D. Hicks, David R. Howell, Stan Kutcher, Carlos Lalonde, Rebekah Mannix, Christina Lin Master, Andrew R. Mayer, Martin H. Osmond, Rébecca Robillard, Kathryn Schneider, Peter Tanuseputro, Ivan Terekhov, Richard J Webster, Cheryl Lea Wellington

4Citations signalées, ce qui n’est pas une note de qualité

34Institutions déclarées

3Pays d’affiliation déclarés

Rattachement africain : ca, us, hk. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

INTRODUCTION: Concussion affects over 400 000 Canadians annually, with a range of causes and impacts on health-related quality of life. Research to date has disproportionately focused on athletes, military personnel and level I trauma centre patients, and may not be applicable to the broader community. The TRANSCENDENT Concussion Research Program aims to address patient- and clinician-identified research priorities, through the integration of clinical data from patients of all ages and injury mechanisms, patient-reported outcomes and objective biomarkers across factors of intersectionality. Seeking guidance from our Community Advisory Committee will ensure meaningful patient partnership and research findings that are relevant to the wider concussion community. METHODS AND ANALYSIS: This prospective observational cohort study will recruit 5500 participants over 5 years from three 360 Concussion Care clinic locations across Ontario, Canada, with a subset of participants enrolling in specific objective assessments including testing of autonomic function, exercise tolerance, vision, advanced neuroimaging and fluid biomarkers. Analysis will be predicated on pre-specified research questions, and data shared with the Ontario Brain Institute's Brain-CODE database. This work will represent one of the largest concussion databases to date, and by sharing it, we will advance the field of concussion and prevent siloing within brain health research. ETHICS AND DISSEMINATION: This study was approved by the Children's Hospital of Eastern Ontario Research Ethics Board and preregistered on OSF (25 June 2024); https://doi.org/10.17605/OSF.IO/HYDZC. Dissemination of findings will be multifaceted, including conference presentations, peer-reviewed publications and sharing of adapted materials (eg, videos, infographics, plain language summaries) with community groups and key knowledge users.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada
Date Crossref: 01/04/2025
Éditeur: BMJ
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

University of Ottawa pays non établi dans la notice
Université ou école supérieure
Children's Hospital of Eastern Ontario pays non établi dans la notice
Établissement de santé
Montfort Hospital pays non établi dans la notice
Établissement de santé
Institut du Savoir Montfort pays non établi dans la notice
Organisation à but non lucratif
Jacobs (United States) pays non établi dans la notice
Entreprise
University of Toronto Rehabilitation Sciences Institute pays non établi dans la notice
Université ou école supérieure
Toronto Rehabilitation Institute pays non établi dans la notice
Établissement de santé
University of British Columbia pays non établi dans la notice
Université ou école supérieure
University of Calgary Hotchkiss Brain Institute pays non établi dans la notice
Université ou école supérieure
Alberta Children's Hospital pays non établi dans la notice
Établissement de santé
Alberta Children's Hospital Research Institute pays non établi dans la notice
Structure de recherche
Hotchkiss Brain Institute pays non établi dans la notice
Université ou école supérieure

University of Ottawa, Children's Hospital of Eastern Ontario et Montfort Hospital, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesCerebral Palsy and Movement Disorders

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