Ruth Davies

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

Gregory Y.H. Lip, Agnieszka Kotalczyk, Christine Teutsch, Hans‐Christoph Diener et autres

BACKGROUND AND PURPOSE: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). METHODS: In GLORIA-AF, …

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Supplementary Material for: Physical Activity in Renal Disease (PAIRED) and the effect on hypertension: a randomized controlled trial

Stephanie Thompson, Natasha Wiebe, Stickland M.K., Gyenes G.T. et autres

Introduction: Exercise is an effective strategy for blood pressure (BP) reduction in the general population, but efficacy for the management of hypertension in CKD is not known. We evaluated the difference in 24-hour ambulatory systolic BP with exercise training in people with …

Development of a staff support service in response to the Covid-19 crisis in Berkshire

Jessica Saunders, Sophie Livsey, Diane Kohl, Linda Piper et autres

This paper summarises reflections, learning and improvements from the experience of having developed a staff support service for frontline healthcare staff in response to the Covid-19 outbreak in Berkshire.

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Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry

George Ntaios, Menno V. Huisman, Hans‐Christoph Diener, Jonathan L. Halperin et autres

The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in …

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The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis

Ruth Davies, Jessica O. Williams, Katie Sime, Charlotte Thompson et autres

OBJECTIVES: Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role …

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CD28− Cells Are Increased in Early Rheumatoid Arthritis and Are Linked With Cytomegalovirus Status

Charlotte Thompson, Ruth Davies, Anwen S. Williams, Gareth W. Jones et autres

Objective CD3+CD8+CD28- cells are higher in Rheumatoid Arthritis (RA). The aim of this study was to assess CD3+CD8+CD28- cells in patients with early RA and assess the effects of cytomegalovirus (CMV) seropositivity. Method In this prospective observation study, fifty RA patients were …

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Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis

Lauren A Jordan, Malin C. Erlandsson, Benjamin F Fenner, Ruth Davies et autres

Objective: Macrophage inflammatory protein 1-alpha (CCL3) is a chemokine that regulates macrophage trafficking to the inflamed joint. The agonistic effect of CCL3 on osteolytic lesions in patients with multiple myeloma is recognized; however, its role in skeletal damage during inflammatory arthritis has …

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Cardiovascular risk factors predicting cardiac events are different in patients with rheumatoid arthritis, psoriatic arthritis, and psoriasis

Roxanne Cooksey, Sinéad Brophy, Jonathan Kennedy, Fabiola Fernandez Gutierrez et autres

OBJECTIVES: Increased cardiovascular risk in rheumatoid arthritis (RA) is well established. Examining traditional cardiovascular risk factors alone underestimates cardiovascular risk in RA. Systematic inflammation, measured by erythrocyte sedimentation rate or C-reactive protein is also a major risk factor. However, the contribution of …

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The role of sIL-6R mediated trans-signaling in cardiovascular morbidity in Rheumatoid Arthritis

Ruth Davies

Cardiovascular mortality in patients with RA is 50% higher than the general population. Although well established that the incidence of CVD is increased, the precise cause is unclear. There is increasing recognition that systemic inflammation is a major driver of increased CV …

Chronic oedema ‘on-the-ground’ education programme

Tessa Watts, Ruth Davies

The impact of chronic oedema on community nurses' work, the NHS and those directly affected by the condition is immense. As chronic oedema prevalence is projected to rise and financial austerity continues, innovative, sustainable solutions that ensure positive outcomes for patients must …

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Preventing cerebral palsy in preterm labour: a multiorganisational quality improvement approach to the adoption and spread of magnesium sulphate for neuroprotection

Anna Burhouse, Charlotte L Lea, Stephen Ray, Hannah Bailey et autres

Magnesium sulphate has been demonstrated to be an effective neuroprotectant for babies delivered prematurely (under 37 weeks' gestational age). Antenatal administration reduces infant mortality and cerebral palsy (CP); however, uptake in the UK has been significantly lower than other countries. A quality …

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THU0025 Il-6 trans-signaling causes accelerated atherosclerosis in disease prone animals

Ruth Davies, Jin Hs, Katie Sime, J. A. Williams et autres

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