Charlotte L Lea

Drainage, irrigation and fibrinolytic therapy (DRIFT) for posthaemorrhagic ventricular dilatation: 10-year follow-up of a randomised controlled trial

Karen Luyt, Sally Jary, Charlotte L Lea, Grace Young et autres

BACKGROUND: Progressive ventricular dilatation after intraventricular haemorrhage (IVH) in preterm infants has a very high risk of severe disability and death. Drainage, irrigation and fibrinolytic therapy (DRIFT), in a randomised controlled trial (RCT), reduced severe cognitive impairment at 2 years. OBJECTIVE: To …

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Drainage, irrigation and fibrinolytic therapy (DRIFT) for posthaemorrhagic ventricular dilatation: 10-year follow-up of a randomised controlled trial

Steven Walker-Cox, Kristian Aquilina, Ian Pople, Andrew G Whitelaw et autres

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Ten-year follow-up of a randomised trial of drainage, irrigation and fibrinolytic therapy (DRIFT) in infants with post-haemorrhagic ventricular dilatation

Karen Luyt, Sally Jary, Charlotte L Lea, Grace Young et autres

Background The drainage, irrigation and fibrinolytic therapy (DRIFT) trial, conducted in 2003–6, showed a reduced rate of death or severe disability at 2 years in the DRIFT compared with the standard treatment group, among preterm infants with intraventricular haemorrhage (IVH) and post-haemorrhagic …

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Drainage, Irrigation and Fibrinolytic Therapy (DRIFT) in Premature Infants with Post-Haemorrhagic Ventricular Dilatation: 10-Year Follow-Up of a Randomised Controlled Trial

Karen Luyt, Sally Jary, Charlotte L Lea, Grace Young et autres

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Preventing cerebral palsy in preterm labour: a multiorganisational quality improvement approach to the adoption and spread of magnesium sulphate for neuroprotection

Anna Burhouse, Charlotte L Lea, Stephen Ray, Hannah Bailey et autres

Magnesium sulphate has been demonstrated to be an effective neuroprotectant for babies delivered prematurely (under 37 weeks' gestational age). Antenatal administration reduces infant mortality and cerebral palsy (CP); however, uptake in the UK has been significantly lower than other countries. A quality …

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Protecting the premature brain: current evidence-based strategies for minimising perinatal brain injury in preterm infants

Charlotte L Lea, Adam Smith‐Collins, Karen Luyt

Improving neurodevelopmental outcome for preterm infants is an important challenge for neonatal medicine. The disruption of normal brain growth and neurological development is a significant consequence of preterm birth and can result in physical and cognitive impairments. While advances in neonatal medicine …

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