Peng Wan

Genetically predicted breastfeeding propensity and brain microstructural morphology: Insights from genome-wide association study summary statistics and neurogenomics

Peng Wan, Liu Zheng, Fengjing Huo, Huiting Gong et autres

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A Generalized State Space Averaging Model for Inverting Four-Switch Buck-Boost Converter

Hongxin Yang, Y Li, Peng Wan, Zhijun Wang et autres

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Associations of Prenatal Exposures to Fine Particulate Matter and Its Compositions with Preterm Birth Risk in Twins

Yuan Zheng, Xinqi Zhong, Peng Wan, Zhiqing Chen et autres

Twin pregnancies have a higher risk of preterm birth (PTB) than single pregnancies, but studies about prenatal air pollution exposure and PTB in twin pregnancies are still scarce. To explore associations of prenatal fine particulate matter (PM2.5) exposure with PTB in twins, …

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Development of the CRISPR/Cas9 system for genome editing in Riemerella anatipestifer

Yi‐Han Chang, Honghao Huang, Ruonan Zhao, Lu Diao et autres

Riemerella anatipestifer (R. anatipestifer) is an important pathogen responsible for high mortality rates and severe economic losses in the poultry industry. Research on R. anatipestifer is constrained by limited genetic manipulation tools, highlighting the need for an effective genome editing toolkit. The …

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A Complement Factor B Mutation in a Chinese Family with Atypical Hemolytic Uremic Syndrome: A Case Report and Systematic Review

Peng Wan, Xicui Long, Hao-Ran Lei, Fengxiao Bu et autres

Introduction: Atypical hemolytic uremic syndrome (aHUS) is a rare and potentially life-threatening condition, often linked to dysregulation of the complement system. Case Presentation: In this study, a novel heterozygous CFB mutation was identified in both the index patient and her sister, who …

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ALKBH5-mediated NPC2 mRNA m6A demethylation promotes resistance to oxaliplatin in colorectal cancer

Peng Wan, Hongtao Li

Colorectal cancer (CRC) is the third most common cancer globally and a leading cause of cancer-related death. Oxaliplatin, a key platinum-based chemotherapy, significantly improves outcomes in CRC patients. Nevertheless, oxaliplatin resistance often emerges, leading to worse prognosis. Exploring new biomarkers and mechanisms …

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CLPP Gene Variants Causing Perrault Syndrome Type 3 in Han Chinese Families: A Genotype-Phenotype Study

Xicui Long, Bingqian Yang, Wei Wang, Peng Wan et autres

BACKGROUND: Perrault syndrome is a rare autosomal recessive disorder characterized by sensorineural hearing loss (SNHL) and primary ovarian insufficiency (POI) secondary to ovarian dysgenesis. However, the mutation spectrum of disease-causing genes for Perrault syndrome in the Chinese population remains poorly understood. In …

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Associations of prenatal exposure to fine particulate matter and its constituents with small for gestational age risk: A twin study in China

Xinqi Zhong, Yuan Zheng, Peng Wan, Yixiang Huang et autres

This study aimed to examine the impact of PM 2.5 and its constituents on small for gestational age (SGA). We collected records of 8082 twin pairs and their mothers from 21 hospitals across China. Concentrations of PM 2.5 and its constituents were …

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Genetic variation in patent foramen ovale: a case-control genome-wide association study

Bosi Dong, Yajiao Li, Fandi Ai, Jia Geng et autres

Background Patent foramen ovale (PFO) is a congenital defect between the atria, resulting in abnormal hemodynamics. We conducted a genome-wide association study (GWAS) to identify common genetic variants associated with PFO. Methods We performed a whole genome sequencing in a discovery cohort …

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Research on Commutation Control Strategy of DC Microgrid Bidirectional Converter

Bi He, Junting Bai, Yunpeng Wang, Peng Wan

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Associations between Gestational Floods Exposure and Preterm Birth in 25 Low- and Middle-Income Countries

Yuan Zheng, Hejie Wang, Peng Wan, Yilin Li et autres

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Analysis of Bacterial Community Composition in Sediments of the Mainstream and Tributaries in the Wanzhou Section of the Three Gorges Reservoir Area, China

Peng Wan, Yu Qin, Zhaoxia Li, Changyue Ouyang et autres

River ecosystems are intricately connected to the biogeochemical processes mediated by sediment bacterial communities. The Three Gorges Reservoir, a critical freshwater resource, has seen limited research on bacterial community composition, particularly in comparative studies between its mainstream and tributaries. High-throughput sequencing was …

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