Zhenhua Ni

Benzo(a)pyrene exposure aggravates airway remodeling in asthma by activating AhR-GDF15 pathway in epithelial cells

Cuiting Shan, Wei Li, Yipeng Sun, Jialu Ma et autres

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Discovery of flavonoids as potent inhibitors of CYP1A to alleviate cellular inflammation and oxidative stress induced by benzo[a]pyrene-induced high CYP1A expression

Xiaodong Li, Nanshan Ma, Chun‐Xian He, Li‐Wei Zou et autres

The environmental pollutant benzo[a]pyrene (BaP) can induce cytochrome P450 family 1 subfamily A (CYP1A) or generate metabolic products that disrupt the balance of oxidative stress, triggering inflammatory responses in the lungs and leading to tissue damage. Flavonoids, known for their natural anti-inflammatory …

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Magnesium is a key trace element in obstructive sleep apnea: evidence from Mendelian randomization analysis and NHANES database

Jing Ma, Wenguan Li, Qingge Chen, Xiongbiao Wang et autres

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Microwave ablation combined with α-PD-L1 enhances abscopal effect and promotes CTL activation and intratumoral homing by a cytokine network involving IFN-γ and CXCL9

Fuqi Ma, Xiayi Miao, Yuhua Lin, Xuming Luo et autres

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Study on the Immunomodulatory effect of Qixian Decoction in an Asthmatic Mice Model Based on Serum Metabolomics

Manman Li, Qingge Chen, Zhenhua Ni, Xinyi Le et autres

Abstract The study aimed to investigate the immunomodulatory effect of Qixian Decoction (QXT) in an asthmatic model. In this study, ovalbumin (OVA)-induced asthma in female SPF BALB/c mice was established. Mice were randomly divided into four groups (n = 8): a control …

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Study of IL-17 and Intercellular Adhesion Molecule-1 in Conjunctivochalasis Using Correlation Analysis

Kai Ma, Huanming Zhou, Wei Zhang, Jiang Liu et autres

PURPOSE: The aim of this study was to observe the expression of interleukin (IL)-17 and intercellular adhesion molecule (ICAM)-1 in conjunctivochalasis (CCH) and to analyze the correlations between cytokines and the severity of CCH. METHODS: Serum samples were collected from 22 patients …

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Microwave ablation enhances the systemic immune response in patients with lung cancer

Fuqi Ma, Yuhua Lin, Zhenhua Ni, Shiqiang Wang et autres

Microwave ablation (MWA) is a key alternative therapy to conventional surgery for the treatment of lung cancer. In addition to eliminating local tumors, MWA may promote antitumor immunological responses, such as abscopal effects in distant lesions. However, the intensity of MWA is …

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Microwave Ablation Combined with Α-Pd-L1 Enhances Abscopal Effect and Promotes Ctl Activation and Intratumoral Homing by a Cytokine Network Involving Ifn-Γ and Cxcl9

fuqi ma, Xiayi Miao, Yuhua Lin, Xuming Luo et autres

Resveratrol Aerosol Inhalation Attenuates Ovalbumin (OVA)‐Induced Asthma in BALB/c Mouse Model

Cuiting Shan, Yue Wu, Lingling Tang, Yuhua Lin et autres

Asthma is a common disease that affects millions of people but has no cure. Resveratrol (Res) has been confirmed to be effective against asthma; however, in vivo experiments had shown that Res administration by either oral or intraperitoneal injection had low absorption, …

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Exploration of the mechanism of Qi-Xian decoction in asthmatic mice using metabolomics combined with network pharmacology

Yuhua Lin, Yue Hui Wu, Fuqi Ma, Cuiting Shan et autres

Introduction: Qi-Xian Decoction (QXD), a traditional Chinese medicine (TCM) formula consisting of eight herbs, has been clinically used to treat asthma. However, the underlying mechanisms have not been completely elucidated. This study aimed to combine metabolomics and network pharmacology to reveal the …

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The mechanism of Sanzi Yangqin decoction for asthma treatment based on network pharmacology and experimental verification

Yue Hui Wu, Zhenhua Ni, Shi‐Qiang Wang, Yipeng Sun et autres

BACKGROUND: Asthma is a chronic airway inflammatory disease characterized by airway inflammation, mucus hypersecretion, airway hyper-reactivity. Sanzi Yangqin Decoction (SZYQD) is widely prescribed for asthma treatment. Its anti-asthma activities have been reported in animal model, but the exact mechanism and targets of …

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Wogonin alleviates BaP‐induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression

Zhenhua Ni, Honghong Ma, Xiaodong Li, Li‐Wei Zou et autres

Benzo[a]pyrene (BaP) is a common air pollutant that has been reported to cause oxidative stress and carcinogenesis. Wogonin, a flavonoid compound extracted from the roots of Scutellaria baicalensis, has been found to possess a variety of pharmacological activities, including anti-inflammatory and anti-cancer …

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