Yuhan Zhao

Operando electrochemiluminescence imaging of intermediate evolution and kinetics in electrocatalytic nitrate reduction

Zhichen Zhang, Zejing Xing, Xiaodan Gou, Jinyang Zhuang et autres

Electrocatalytic nitrate reduction (NO3RR) provides a sustainable approach for removing nitrate pollutants and producing valuable nitrogen chemicals. However, understanding catalytic behavior under realistic dilute conditions remains challenging, as conventional electrochemical measurements rely on ensemble-averaged signals that obscure dynamic interfacial processes at individual …

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Decoding the impact of surfactants on the interaction between Lipase TpS9 and pNPP through molecular docking and MD simulations

Yuhan Zhao, Lin Chen, Lixin Duan, Ruige Wang

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Integrated network toxicology, molecular docking, molecular dynamics simulation, and experimental verification to elucidate the mechanism of hepatotoxicity and processing detoxification in Fructus Meliae Toosendan

Shan Ran, Dongshi Gu, Yuhan Zhao, Yujuan Liu et autres

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A Ratiometric SERS Strategy Based on a WO3/W18O49 Homojunction Substrate with Built-In Raman Internal Standard for Accurate Trace Antibiotic Detection

Lu Tan, Yuhan Zhao, Pengyu Zhou, Jun‐Jie Zhu et autres

Accurate detection of trace antibiotics in complex matrices remains a major analytical challenge. In this study, we report a distinctive ratiometric surface-enhanced Raman scattering (SERS) strategy involving a non-noble metal WO 3 /W 18 O 49 homojunction substrate for this purpose. The …

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DNA Nanotubule‐Based Nanodevices with ATP‐Responsive Gating for Direct Cytosolic Delivery of Nucleic Acids and Proteins

Di Gao, Ziqi Xu, Xiangli Li, Yuhan Zhao et autres

Delivering biomacromolecules to the cytosol remains a formidable challenge, as these molecules are predominantly sequestered within endosomes after endocytosis. The limited efficacy of current delivery systems in promoting reliable endosomal escape underscores the need for innovative strategies. Here, we report a DNA …

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A network pharmacology approach-based decoding of Resveratrol's anti-fibrotic mechanisms

Yongheng Wang, Ning Li, Jiahao Hu, Yuhan Zhao et autres

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DNA-DISK: Automated end-to-end data storage via enzymatic single-nucleotide DNA synthesis and sequencing on digital microfluidics

Kunjie Li, Xiaoyun Lu, Jiaqi Liao, Heng Chen et autres

In the age of information explosion, the exponential growth of digital data far exceeds the capacity of current mainstream storage media. DNA is emerging as a promising alternative due to its higher storage density, longer retention time, and lower power consumption. To …

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A unique mode of coenzyme A binding to the nucleotide binding pocket of human metastasis suppressor NME1

Maria‐Armineh Tossounian, Stefan Denchev Hristov, Jonathan A. Semelak, Bess Yi Kun Yu et autres

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Low-molecular-weight thiol transferases in redox regulation and antioxidant defence

Maria‐Armineh Tossounian, Yuhan Zhao, Bess Yi Kun Yu, Samuel A. Markey et autres

Low-molecular-weight (LMW) thiols are produced in all living cells in different forms and concentrations. Glutathione (GSH), coenzyme A (CoASH), bacillithiol (BSH), mycothiol (MSH), ergothioneine (ET) and trypanothione T(SH)2 are the main LMW thiols in eukaryotes and prokaryotes. LMW thiols serve as electron …

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A Unique Mode of Coenzyme A Binding to the Nucleotide Binding Pocket of Human Metastasis Suppressor NME1

Maria‐Armineh Tossounian, Stefan Denchev Hristov, Jonathan A. Semelak, Bess Yi Kun Yu et autres

Coenzyme A (CoA) is a key cellular metabolite which participates in diverse metabolic pathways, regulation of gene expression and the antioxidant defense mechanism. Human NME1 (hNME1), which is a moonlighting protein, was identified as a major CoA-binding protein. Biochemical studies showed that …

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