Kui Yu

CUL2 confers ferroptosis resistance in pancreatic cancer by disrupting KEAP1-mediated NRF2 degradation

Kui Yu, Lili Chen, Yong Zhong, Yang Wang et autres

BACKGROUND: Pancreatic cancer (PC) is characterized by high chemoresistance and poor prognosis. CUL2, a scaffold protein of E3 ubiquitin ligases, has been implicated in tumor progression, but its role in PC remains unclear. METHODS: CUL2 expression was analyzed in PC tissues and …

cn (code pays fourni par la source)

WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer

Yang Wang, Dachuan Qi, Gaoxiang Ge, N. Cao et autres

Chemoresistance continues to pose a significant challenge in managing colorectal cancer (CRC), resulting in unfavorable outcomes for patients. Recent findings indicate that ferroptosis, an innovative type of regulated cell death, might influence chemoresistance. In this research, we explored how WW domain-binding protein …

cn (code pays fourni par la source)

Chlorogenic acid alleviates the development of severe acute pancreatitis by inhibiting NLPR3 Inflammasome activation via Nrf2/HO-1 signaling

Zhen Ye, Lin Cheng, Kui Yu, Jiang Li et autres

Severe acute pancreatitis (SAP), marked by profound tissue inflammation within the pancreatic tissue, is an abrupt and intense inflammation of the pancreas. Chlorogenic acid (CGA) is one of the effective pharmacological ingredients components in JinHong Tablet (JHT). The role of CGA in …

cn (code pays fourni par la source)

Inversion for offshore oil-water emulsion concentration based on a six-flux model of laser-induced fluorescence

Xiaodan Zhang, Zhenxue He, Fangfang Liang, Jie Dong et autres

Oil-water emulsions, as one of the momentous weathering forms of the marine oil-spill, have caused more severe detriment to the marine environment. Laser-induced fluorescence (LIF) is an extremely influential technique for monitoring spilled oil at sea. However, the evaluation of offshore oil-water …

cn (code pays fourni par la source)

Solasonine Inhibits Pancreatic Cancer Progression With Involvement of Ferroptosis Induction

Xiaoqiang Liang, Cheng Hu, Mian Han, Congying Liu et autres

Pancreatic cancer is a highly fatal malignant tumor of the digestive system. It is characterized by early metastasis and high mortality rates. Solasonine, a steroidal alkaloid, is derived from Solanum nigrum L. , a natural herb. Solasonine is associated with excellent anti-tumor …

cn (code pays fourni par la source)

Anhydroicaritin Inhibits EMT in Breast Cancer by Enhancing GPX1 Expression: A Research Based on Sequencing Technologies and Bioinformatics Analysis

Feifei Li, Youyang Shi, Xiaojuan Yang, Zhanyang Luo et autres

Background: Breast cancer (BC) is the leading cause of cancer-related deaths among women worldwide. The application of advanced technology has promoted accurate diagnosis and treatment of cancer. Anhydroicaritin (AHI) is a flavonoid with therapeutic potential in BC treatment. The current study aimed …

cn (code pays fourni par la source)

Dahuang Danshen Decoction Inhibits Pancreatic Fibrosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

Xiaoqiang Liang, Mian Han, Xuelin Zhang, Xun Sun et autres

Background. In Traditional Chinese Medicine (TCM), Dahuang Danshen decoction (DD) is used to treat pancreatic fibrosis. Pancreatic fibrosis is a typical manifestation of chronic pancreatitis (CP), which affects the digestive system. The therapeutic mechanisms of DD in pancreatic fibrosis are unclear. Aim. …

cn (code pays fourni par la source)

Traditional Chinese medicine Bu-Shen-Jian-Pi-Fang attenuates glycolysis and immune escape in clear cell renal cell carcinoma: results based on network pharmacology

Jinzhou Zheng, Wenhao Xu, Wangrui Liu, Haijia Tang et autres

Clear cell renal cell carcinoma (ccRCC) is the most common malignant type of kidney cancer. The present study aims to explore the underlying mechanism and potential targets of the traditional Chinese medicine Bu-Shen-Jian-Pi-Fang (BSJPF) in the treatment of ccRCC based on network …

cn (code pays fourni par la source)

Dihydrokaempferol (DHK) ameliorates severe acute pancreatitis (SAP) via Keap1/Nrf2 pathway

Xiaoqiang Liang, Cheng Hu, Congying Liu, Kui Yu et autres

cn (code pays fourni par la source)

Screening, identification and validation of CCND1 and PECAM1/CD31 for predicting prognosis in renal cell carcinoma patients

Jianfeng Yang, Shen-Nan Shi, Wenhao Xu, Yunhua Qiu et autres

. In summary, integrated bioinformatics analysis identified candidate DEGs and pathways in ccRCC that could improve our understanding of the causes and underlying molecular events of ccRCC. These candidate genes and pathways could be therapeutic targets for ccRCC.

cn (code pays fourni par la source)

Emodin inhibits epithelial‑mesenchymal transition and metastasis of triple negative breast cancer via antagonism of CC‑chemokine ligand�5 secreted from adipocytes

Xiaoyun Song, Xiqiu Zhou, Yuenong Qin, Jianfeng Yang et autres

Triple negative breast cancer (TNBC) has the lowest survival rate of the breast cancer subtypes owing to its aggressive and metastatic behavior. It has been reported that peritumoral adipose tissue contributes to the cell invasiveness and dissemination of TNBC. Emodin is an …

cn (code pays fourni par la source)

Risk factors for suboptimal drug concentration of posaconazole oral suspension in patients with hematologic malignancy

E.J. Kim, Kui Yu, S.H. Na, Eun-Sook Nam et autres

kr, Éthiopie, pr (code pays fourni par la source)