Yuki Hamada

Reply to Critique on “Severe cerebral small vessel disease burden is associated with intraventricular extension of intracerebral hemorrhage”

Takeo Sato, Yuka Tsuchimochi, Yuki Hamada, Kaishi Kukihara et autres

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Gut microbial metabolite butyrate boosts p53-expressing telomerase-specific oncolytic adenovirus efficacy by enhancing infectivity and activating MHC-I/cGAS-STING

Masaki Sakamoto, Shinji Kuroda, Tetsuya Katayama, Yu Mikane et autres

The gut microbiota plays an essential role in regulating host immunity, and its metabolites such as butyrate exert immunomodulatory effects by acting as histone deacetylase inhibitors. Oncolytic virotherapy has emerged as a promising approach for cancer treatment, and we have developed OBP-702, …

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Fibrosis-4 index and prognosis and hematoma volume: association with lobar and non-lobar intracerebral hemorrhage

Takeo Sato, Yuka Tsuchimochi, Yuki Hamada, Kaishi Kukihara et autres

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Severe cerebral small vessel disease burden is associated with intraventricular extension of intracerebral hemorrhage

Takeo Sato, Yuka Tsuchimochi, Yuki Hamada, Kaishi Kukihara et autres

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Serum extracellular vesicles containing adenoviral E1A-DNA as a predictive biomarker for liquid biopsy in oncolytic adenovirus therapy

Chiaki Yagi, Shinji Kuroda, Yoshihiko Kakiuchi, Shunya Hanzawa et autres

Oncolytic adenoviruses replicate selectively in tumor cells and induce immunogenic cell death, but predictive biomarkers for early therapeutic response are lacking. This study evaluated extracellular vesicle-encapsulated adenoviral E1A-DNA (EV-E1A-DNA) as a minimally invasive biomarker for monitoring responses to telomerase-specific oncolytic adenoviruses OBP-301 …

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The combination of atrial fibrillation and small vessel disease score worsen spontaneous intracerebral hemorrhage outcomes

Yuki Hamada, Takeo Sato, Hideki Matsuoka, Yuka Tsuchimochi et autres

Background This study aimed to examine whether the presence of atrial fibrillation (AF), severity as judged by total small vessel disease (SVD) score, or a combination of these is associated with prognosis and hematoma volume of spontaneous intracerebral hemorrhage (sICH). Methods This …

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Serum Extracellular Vesicles Containing Adenoviral E1A-DNA as a Predictive Biomarker for Liquid Biopsy in Oncolytic Adenovirus Therapy

Chiaki Yagi, Shinji Kuroda, Yoshihiko Kakiuchi, Shunya Hanzawa et autres

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Lower high-density lipoprotein cholesterol level is associated with hematoma expansion in acute intracerebral hemorrhage: association with hypertensive microangiopathy

Takeo Sato, Yuka Tsuchimochi, Yuki Hamada, Kaishi Kukihara et autres

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Pulmonary Cryptococcosis During Osimertinib Treatment for Epidermal Growth Factor Receptor (EGFR) L858R-Mutant Lung Adenocarcinoma: A Case Report

Yuki Hamada, Toshiaki Motegi, Kenya Kuramoto, Tatsuya Akiyama et autres

Pulmonary cryptococcosis is a rare but important opportunistic fungal infection that may occur during epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer. We describe the case of a woman in her 60s receiving osimertinib for EGFR L858R-mutant lung adenocarcinoma …

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Abstract TMP72: Lower High-Density Lipoprotein Cholesterol Level Is Associated With Hematoma Expansion Following Acute Intracerebral Hemorrhage

Takeo Sato, Yuka Tsuchimochi, Yuki Hamada, Yutaro Kawabata et autres

Background&Aims: A certain lipoprotein, especially lower low-density lipoprotein cholesterol (LDL-C), has been said to be a risk of developing intracerebral hemorrhage (ICH). However, the correlation between lipoprotein levels and hematoma expansion (HE) following ICH remains unknown. We aimed to elucidate the relation …

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Gut Microbial Butyrate Boosts P53-Expressing Telomerase-Specific Oncolytic Adenovirus Efficacy by Enhancing Infectivity and Activating Mhc-I and the Cgas-Sting Pathway

Masaki Sakamoto, Shinji Kuroda, Tetsuya Katayama, Yu Mikane et autres

jp (code pays fourni par la source)

The Vascular Endothelial Growth Factor-A121/Vascular Endothelial Growth Factor-A165 Ratio as a Predictor of the Therapeutic Response to Immune Checkpoint Inhibitors in Gastric Cancer

Yuki Hamada, Kiyonori Tanoue, Takaaki Arigami, Munekazu Yamakuchi et autres

Background/Objectives: The response rate to immune checkpoint inhibitor (ICI) therapy is limited. Further, there is a need to discover biomarkers to predict therapeutic efficacy. The vascular endothelial growth factor (VEGF) is strongly associated with intra-tumoral immunity; however, its utility as a marker …

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