John C. Moore

Endothelial Notch signalling limits angiogenesis via control of artery formation

Sana S. Hasan, Roman Tsaryk, Laura Wisniewski, John C. Moore et autres

de, us, pl (code pays fourni par la source)

Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish

John C. Moore, Qin Tang, Nora Torres Yordán, Finola E. Moore et autres

Cell transplantation into immunodeficient mice has revolutionized our understanding of regeneration, stem cell self-renewal, and cancer; yet models for direct imaging of engrafted cells has been limited. Here, we characterize zebrafish with mutations in recombination activating gene 2 (rag2), DNA-dependent protein kinase …

us (code pays fourni par la source)

T Cell Immune Deficiency in zap70 Mutant Zebrafish

John C. Moore, Timothy S. Mulligan, Nora Torres Yordán, Daniel Castranova et autres

ZAP70 [zeta-chain (TCR)-associated protein kinase, 70-kDa], is required for T cell activation. ZAP70 deficiencies in humans and null mutations in mice lead to severe combined immune deficiency. Here, we describe a zap70 loss-of-function mutation in zebrafish (zap70y442) that was created using transcription …

us, ca (code pays fourni par la source)

Abstract 4177: Dynamic visualization of cancer cell engraftment into immune compromised zebrafish

John C. Moore, Qin Tang, Nora Torres Yordán, Timothy S. Mulligan et autres

Abstract Cell transplantation into immune compromised mice has transformed our understanding of cancer and is now the gold standard for assessing therapeutic responses in vivo. However, mouse models are expensive and engraftment is often difficult to visualize directly. To overcome these challenges, …

us, ca (code pays fourni par la source)

Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish

Finola E. Moore, Elaine G. Garcia, Riadh Lobbardi, Esha Jain et autres

Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish

Finola E. Moore, Elaine G. Garcia, Riadh Lobbardi, Esha Jain et autres

Hematopoiesis culminates in the production of functionally heterogeneous blood cell types. In zebrafish, the lack of cell surface antibodies has compelled researchers to use fluorescent transgenic reporter lines to label specific blood cell fractions. However, these approaches are limited by the availability …

us (code pays fourni par la source)

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

Qin Tang, John C. Moore, Myron S. Ignatius, Inês M. Tenente et autres

Cancers contain a wide diversity of cell types that are defined by differentiation states, genetic mutations and altered epigenetic programmes that impart functional diversity to individual cells. Elevated tumour cell heterogeneity is linked with progression, therapy resistance and relapse. Yet, imaging of …

us, pt, gb (code pays fourni par la source)

Allograft Cancer Cell Transplantation in Zebrafish

John C. Moore, David M. Langenau

us (code pays fourni par la source)

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

Inês M. Tenente, Qin Tang, John C. Moore, David M. Langenau

Zebrafish have become a powerful tool for assessing development, regeneration, and cancer. More recently, allograft cell transplantation protocols have been developed that permit engraftment of normal and malignant cells into irradiated, syngeneic, and immune compromised adult zebrafish. These models when coupled with …

pt, us (code pays fourni par la source)

Optimized cell transplantation using adult rag2 mutant zebrafish

Qin Tang, Nouran S. Abdelfattah, Jessica S. Blackburn, John C. Moore et autres

us, ca (code pays fourni par la source)

Distinct Notch signaling outputs pattern the developing arterial system

Aurélie Quillien, John C. Moore, Masahiro Shin, Arndt F. Siekmann et autres

Differentiation of arteries and veins is essential for the development of a functional circulatory system. In vertebrate embryos, genetic manipulation of Notch signaling has demonstrated the importance of this pathway in driving artery endothelial cell differentiation. However, when and where Notch activation …

us (code pays fourni par la source)

Post-transcriptional mechanisms contribute to Etv2 repression during vascular development

John C. Moore, Sarah Sheppard-Tindell, Ilya Shestopalov, Sayumi Yamazoe et autres

us (code pays fourni par la source)