Sayan Mullick Chowdhury

Multi-omic characterization of 14q deletion in renal clear cell carcinoma identifies EDNRB as a predictor of immunotherapy response

Raven Vella, Emily L. Hoskins, Ira D Miller, Julie W Reeser et autres

Background Although chromosome 14q deletion (14q−) is present in up to 40% of clear cell renal cell carcinoma (ccRCC) cases, its immunologic and molecular impact remains unclear. Because TRAF3 and NFΚBIA , key regulators of nuclear factor kappa-light-chain-enhancer of activated B cells …

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Circulating tumor DNA dynamics as a predictive biomarker of response and survival in metastatic urothelial carcinoma treated with enfortumab vedotin and pembrolizumab.

Lingbin Meng, Yuanquan Aaron Yang, Sayan Mullick Chowdhury, Eric Fei Hong et autres

860 Background: On treatment biomarkers that connect molecular clearance to clinical outcomes are needed in metastatic urothelial carcinoma (mUC). We tested whether circulating tumor DNA (ctDNA) kinetics, especially ctDNA negativity, track response and survival during enfortumab vedotin plus pembrolizumab (EV+pembro) treatment. Methods: …

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Permissive Cardiotoxicity: Real World Outcomes of CAR-T Therapy in Patients with Heart Failure and Reduced Ejection Fraction

Sree M Lanka, Sayan Mullick Chowdhury, Jeremy Sen, Isaiah Boateng et autres

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CD34 selected stem cell boost provides robust outcomes in patients with poor graft function

Sayan Mullick Chowdhury, Qiuhong Zhao, Sarah Wall, Hannah Choe et autres

Abstract Background: Allogenic stem cell transplantation (SCT) is a curative option in several hematological malignancies. However, patients that have poor graft function (PGF) have increased non-relapse mortality as therapeutic options for PGF are currently limited. Larocca et al had first reported the …

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1229 14q deletion in renal clear cell carcinoma is associated with increased anti-tumor immunity and improved response to PD-1 checkpoint blockade potentially driven by NF-κB signaling

Raven Vella, Emily L. Hoskins, Michele R. Wing, Julie W. Reeser et autres

Background Renal clear cell carcinoma (ccRCC) is a deadly cancer treated with immune checkpoint blockade (ICB). 1 Despite large ccRCC trials, no predictive biomarkers for ICB success have been identified.1 Although 14q- is present in up to 40% of ccRCC cases, its …

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Trends of Authors' Conflicts of Interest in Clinical Trials Published in the Journal of Clinical Oncology : A Large Language Model–Assisted Longitudinal Study

Jiasheng Wang, Pedro C. Silberman, Sayan Mullick Chowdhury, Bradley W. Blaser

PURPOSE Conflicts of interest (COIs) between clinical trial investigators and biopharmaceutical companies have raised concerns about potential bias in research. This study aimed to systematically analyze the prevalence and trends of COIs in oncology clinical trials published in the Journal of Clinical …

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Analysis of conflicts of interest in clinical trials published in JCO: A large language model-assisted longitudinal study.

Jia-Sheng Wang, Sayan Mullick Chowdhury, Pedro C. Silberman, Bradley W. Blaser

e23042 Background: Conflicts of interest (COIs) in oncology trials, particularly those arising from industry funding and author affiliations, may influence the objectivity of clinical trial findings. The manual identification of medical products and corresponding pharmaceutical companies, as well as author COIs from …

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Virtual oncology collaborative tumor board using multiple artificial intelligence agents.

Jia-Sheng Wang, Sayan Mullick Chowdhury, Aziz Nazha

1563 Background: Clinical guidelines are complex documents with tables and figures. Finding specific answers to questions within these guidelines can be challenging and time-consuming. Current AI tools often struggle to extract information from these PDF guidelines. To address this, we developed a …

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CNPY2 in Solid Tumors: Mechanisms, Biomarker Potential, and Therapeutic Implications

Sayan Mullick Chowdhury, Feng Hong, Christian Rolfo, Zihai Li et autres

Canopy FGF signaling regulator 2 (CNPY2) has emerged as a crucial player in cancer development by promoting cell proliferation, tissue repair, and angiogenesis. This review synthesizes the current understanding of CNPY2's role in solid tumors, particularly renal cell carcinoma, prostate cancer, hepatocellular …

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Impact of circulating lymphoma cells at diagnosis on outcomes in patients with newly diagnosed de novo diffuse large B-cell lymphoma

Sayan Mullick Chowdhury, Subodh Bhatta, Timothy Voorhees, Kaitlin Annunzio et autres

Diffuse large B-cell lymphoma (DLBCL), the most common B-cell non-Hodgkin lymphoma rarely presents with circulating lymphoma cells (CL) at diagnosis. Previous studies were limited by small sample size precluding robust analysis. Hence, we evaluated the prognostic relevance of CL cells in newly …

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Design of a Multi-Band Printed Yagi-Uda antenna for CubeSat Communication

Kajal Sinha, Sayan Mullick Chowdhury, Gobinda Sen

This work illustrated a multiband CPW feed printed yagi-uda antenna tailored for CubeSat applications. The proposed structure is designed on a low-cost glass epoxy substrate of permittivity 4.4 and loss tangent 0.02 and having dimensions of 100 × 100 mm2, which can …

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CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia

Francesco Mazziotta, Luca Biavati, Joseph Rimando, Sergio Rutella et autres

ABSTRACT: The interplay between T-cell states of differentiation, dysfunction, and treatment response in acute myeloid leukemia (AML) remains unclear. Here, we leveraged a multimodal approach encompassing high-dimensional flow cytometry and single-cell transcriptomics and found that early memory CD8+ T cells are associated …

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