Multi-omic characterization of 14q deletion in renal clear cell carcinoma identifies EDNRB as a predictor of immunotherapy response
Raven Vella, Emily L. Hoskins, Ira D Miller, Julie W Reeser et autres
Background Although chromosome 14q deletion (14q−) is present in up to 40% of clear cell renal cell carcinoma (ccRCC) cases, its immunologic and molecular impact remains unclear. Because TRAF3 and NFΚBIA , key regulators of nuclear factor kappa-light-chain-enhancer of activated B cells …
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Journal for ImmunoTherapy of Cancer