Hiroshi Koyama

Impact of code stroke on door-to-andexanet administration time for factor Xa inhibitor-associated intracranial hemorrhage: a single-center retrospective study

Koji Tanaka, Eri Imazu, Takuma Ishihara, Junpei Koge et autres

Background Administration of andexanet alfa has shown to achieve hemostatic efficacy in factor Xa inhibitor (FXai)-associated intracranial hemorrhage (ICrH). Code stroke (CS), implemented through the visual task management application Task Calc. Stroke (TCS) facilitates timely reperfusion therapy for acute ischemic stroke. However, …

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Association between nafamostat mesylate infusion dose and dialysis circuit occlusion in continuous renal replacement therapy: a retrospective cohort study

Naoto Eriguchi, Kiyomitsu Fukaguchi, Mochida Yasuhiro, Hiroshi Koyama

Abstract Background Circuit occlusion during treatment is detrimental in patients undergoing continuous renal replacement therapy (CRRT), leading to treatment interruption, reduced clearance efficiency, and increased healthcare costs. Nafamostat mesylate (NM) is an anticoagulant commonly used during CRRT, particularly in patients with a …

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Metformin-Associated Lactic Acidosis Induced by Even Modest Amounts of Alcohol: A Case Report

Kiyomitsu Fukaguchi, Hiroshi Koyama, Masatoshi Nakamura

A 66-year-old man with type 2 diabetes mellitus, treated with metformin, experienced loss of consciousness after bathing and consuming approximately 700 mL of beer (estimated 28 g of alcohol). He had no history of habitual heavy drinking. Upon arrival at the emergency …

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Association between pet ownership and physical function at discharge in hospitalized older adults: A retrospective observational study

Yo Ishihara, Kiyomitsu Fukaguchi, Hiroshi Koyama

OBJECTIVES: Hospitalization can lead to a loss of physical function among older adults. While pet ownership has been reported to have beneficial effects on physical function, its impact on hospitalized patients remains unclear. We examined the association between pet ownership upon admission …

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Aortoesophageal Fistula-Induced Rare Life-Threatening Hematemesis in the Emergency Department: A Case Series and Literature Review

Masahiro Kobayashi, Kiyomitsu Fukaguchi, Hiroshi Koyama, Azusa Taguchi et autres

Background and objective Aortoesophageal fistula (AEF) is a rare but life-threatening condition. It is often challenging to promptly diagnose AEF given the diversity of chief complaints and clinical presentations at the time of initial treatment. In some cases, upper gastrointestinal endoscopy is …

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Anthropogenic gadolinium in the Tone River (Japan): an update showing a 7.7-fold increase from 1996 to 2020

Soma Kumasaka, A. Adhipatria P. Kartamihardja, Yuka Kumasaka, Satomi Kameo et autres

BACKGROUND: Anthropogenic gadolinium (Gd), originating from Gd-based contrast agents (GBCAs) used in magnetic resonance imaging (MRI), is widely identified in the aquatic environment with concerns about toxicity and accumulation. We aimed to present new data on anthropogenic Gd in the Tone River, …

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Severe Hyperammonemia Due to Fecal Bowel Obstruction With a Congenital Portosystemic Shunt Resulting in Refractory Status Epilepticus and Cerebral Edema

Tetsuro Kawakami, Kiyomitsu Fukaguchi, Naoko Isogai, Hiroshi Koyama

Hyperammonemic encephalopathy is a neurological emergency that can lead to seizures and cerebral edema. Although early interventions have been suggested, no clear criteria have been established. Herein, we report a case of severe non-hepatic hyperammonemia resulting in refractory status epilepticus within a …

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Validation of the prognosis of patients with ER‑positive, HER2‑negative and node‑negative invasive breast cancer classified as low risk by Curebest™ 95GC Breast in a multi‑institutional registry study

Yasuto Naoi, Ryo Tsunashima, Kenzo Shimazu, Masahiro Oikawa et autres

Curebest™ 95GC breast (95GC) is a multigene classifier we developed for the prognostic prediction of patients with estrogen receptor (ER)‑positive, human epidermal growth factor receptor 2 (HER2)‑negative and node‑negative (ER+/HER2‑/n0) invasive breast cancer treated with adjuvant endocrine therapy alone. The aim of …

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Supplementary Methods, Figure Legends 1-3 from Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

Nobutaka Kobayashi, Seiji Miyoshi, Takahide Mikami, Hiroshi Koyama et autres

Supplementary Methods, Figure Legends 1-3 from Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

Supplementary Figure 2 from Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

Nobutaka Kobayashi, Seiji Miyoshi, Takahide Mikami, Hiroshi Koyama et autres

Supplementary Figure 2 from Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

Supplementary Figure 3 from Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

Nobutaka Kobayashi, Seiji Miyoshi, Takahide Mikami, Hiroshi Koyama et autres

Supplementary Figure 3 from Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

Supplementary Figure 1 from Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

Nobutaka Kobayashi, Seiji Miyoshi, Takahide Mikami, Hiroshi Koyama et autres

Supplementary Figure 1 from Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization