Denia Frank

Evaluation of a phage-inclusive multimodal strategy for recurrent urinary tract infections

Simone C. Lieberknecht-Jouy, Thomas Fließwasser, Dajana Pavlović, Lucas J. Fein et autres

Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and are associated with high recurrence rates and substantial morbidity. New therapeutic approaches are urgently needed, especially for recurrent UTIs (rUTIs), among which phage therapy represents a promising option. Here, …

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Additional file 1 of Evaluation of a phage-inclusive multimodal strategy for recurrent urinary tract infections

Simone C. Lieberknecht-Jouy, Thomas Fließwasser, Dajana Pavlović, Lucas J. Fein et autres

Supplementary Material 1.

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Additional file 1 of Evaluation of a phage-inclusive multimodal strategy for recurrent urinary tract infections

Simone C. Lieberknecht-Jouy, Thomas Fließwasser, Dajana Pavlović, Lucas J. Fein et autres

Supplementary Material 1.

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Global lineages of non-tuberculous mycobacteria in residential water samples from Germany

Margo Diricks, Denia Frank, Inna Friesen, Stefan Niemann et autres

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause severe infections in vulnerable individuals. However, the environmental reservoirs and transmission routes of clinically relevant NTM remain insufficiently understood. Given the rising incidence of NTM infections, understanding where these bacteria thrive can …

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Sustainable Joullie–Ugi and Continuous Flow Implementation Led to Novel Captopril-Inspired Broad-Spectrum Metallo-β-Lactamase Inhibitors

Antonella Ilenia Alfano, Sveva Pelliccia, Simona Barone, Luigi Cutarella et autres

Metallo-β-lactamases (MBL) production is one of the most alarming bacterial resistance mechanisms, conferring broad-spectrum resistance to most β-lactam antibiotics and combinations with β-lactamase inhibitors. Since no MBL inhibitors have been approved yet, the quest for novel, safe, and effective compounds, possibly endowed …

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Integrating Siderophore Substructures in Thiol-Based Metallo-β-Lactamase Inhibitors

Marco J. Rotter, Sabrina Zentgraf, Lilia Weizel, Denia Frank et autres

Metallo beta lactamases (MBLs) are among the most problematic resistance mechanisms of multidrug-resistant Gram-negative pathogens due to their broad substrate spectrum and lack of approved inhibitors. In this study, we propose the integration of catechol substructures into the design of thiol-based MBL …

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N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Cansu Kaya, Jelena Konstantinović, Andreas M. Kany, Anastasia Andreas et autres

Drug-resistant pathogens pose a global challenge to public health as they cause diseases that are extremely difficult to cure. Metallo-β-lactamases (MBLs) are a diverse set of zinc-containing enzymes that catalyze the hydrolysis of β-lactam drugs, including carbapenems, which are considered as the …

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Cover Feature: RhII‐Catalyzed De‐symmetrization of Ethane‐1,2‐dithiol and Propane‐1,3‐dithiol Yields Metallo‐β‐lactamase Inhibitors (ChemMedChem 22/2021)

Mikhail Krasavin, Daniil Zhukovsky, Igor V. Solovyev, Darina Barkhatova et autres

The Cover Feature shows the general mode of action of thiol-based metallo-beta-lactamase inhibitors. The hero in the desert represents a person administering such an inhibitor. The whip in his hands (with the thiol group at the end) represents the monothiol metallo-beta-lactamase inhibitor …

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Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases

Anna Proschak, Giada Martinelli, Denia Frank, Marco J. Rotter et autres

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RhII‐Catalyzed De‐symmetrization of Ethane‐1,2‐dithiol and Propane‐1,3‐dithiol Yields Metallo‐β‐lactamase Inhibitors

Mikhail Krasavin, Daniil Zhukovsky, Igor V. Solovyev, Darina Barkhatova et autres

Diversity-oriented synthesis (DOS) is a rich source for novel lead structures in Medicinal Chemistry. In this study, we present a DOS-compatible method for synthesis of compounds bearing a free thiol moiety. The procedure relies on Rh(II)-catalyzed coupling of dithiols to diazo building …

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N -Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

Samir Yahiaoui, Katrin Voos, Jörg Haupenthal, Thomas A. Wichelhaus et autres

isolates, where they restored the full activity of imipenem. Together with their LasB-inhibitory activity in the micromolar range, this class of compounds can now serve as a starting point for a multi-target inhibitor approach against both bacterial resistance and virulence, which is …

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Rücktitelbild: Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (Angew. Chem. 52/2019)

Edna Bode, Antje K. Heinrich, Merle Hirschmann, Desalegne Abebew et autres

Die gezielte Aktivierung von Biosynthesegenclustern in Δhfq-Mutanten verschiedener Proteobakterien vereinfacht die Isolierung und biologische Testung der dadurch exklusiv produzierten Naturstoffe, wie E. Bode et al. in ihrem Forschungsartikel auf S. 19133 zeigen. easyPACId (“Easy promoter activated compound identification”) aktiviert auch stille Gencluster, …

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