Accès ouvert
2025
article
OpenAlex
Adam Khader, Beth Rider, Catherine Frakes Vozzo, Munazza Anis et autres
Pancreaticobiliary maljunction (PBM) is a congenital anomaly that predisposes patients to recurrent pancreatitis, choledocholithiasis, and an increased risk of biliary tract malignancy. In patients without biliary dilatation, standard management typically consists of cholecystectomy with endoscopic biliary decompression. However, management can be challenging …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Zheng Liu, An Nguyen, Amy L. Olex, Mikail Bala et autres
Abstract The effectiveness of current cancer immunotherapies, such as immune checkpoint blockade (ICB), adoptive T cell therapy (ACT), and chimeric antigen receptor (CAR) T-cell therapy, is limited in solid tumors due to the scarcity of tumor-specific immunogenic targets, impaired tumor antigen processing, …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Evan W. Davis, Margaret A. Park, Toni L. Basinski, J. Pablo Arnoletti et autres
Abstract Background: Image based body composition is the gold standard for assessing skeletal muscle area and quality in cancer patients. In patients with pancreatic ductal adenocarcinoma (PDAC), the decrease in muscle area and quality can be particularly profound. Yet image-based muscle assessment …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Aslamuzzaman Kazi, Hitesh Kumar Kantilal Vasiyan, Deblina Ghosh, Dipankar Bandyopadhyay et autres
Abstract Discovery of sotorasib is a major breakthrough for KRAS G12C targeted therapies. However, overall response rates of patients with KRAS G12C lung cancer treated with sotorasib are modest due to resistance mediated by adaptive reactivation of ERK, which requires wild-type (WT) …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Amelia R. Malicki, Leslie M. Ogilvie, Alexa N. King, Patrick Sanosa et autres
Abstract Introduction: Chemotherapy and radiation treatment cause cardiac injury and dysfunction. It remains unclear how cancer affects cardiac structure and function in therapy-naïve mice. Emerging data shows that epithelial ovarian cancer affects hemodynamics by causing cardiac atrophy, intrinsic cardiac dysfunction and arterial …
ca, us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Erica J. Peterson, Vignesh Vudatha, Vashti L. Bandy, Praveen Bhoopathi et autres
Abstract Patients with the most common pancreatic malignancy, pancreatic ductal adenocarcinomas (PDAC), typically present with advanced disease and their cancer progresses 6-12 months after treatment with the front-line regimen, FOLFIRINOX (5-fluorouracil, oxaliplatin, irinotecan and leucovorin). Therefore, there is a critical need for …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Vashti L. Bandy, Adam Khader, Praveen Bhoopathi, Vignesh Vudatha et autres
Abstract Colorectal cancer (CRC) is highly treatable when localized, but survival drops sharply with metastasis, especially to the peritoneum (PM). CRC PM is particularly resistant to chemotherapy, emphasizing the need for models that replicate disease biology for use in drug discovery. Our …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Nina M. Dashti-Gibson, Amy L. Olex, Katarzyna M. Tyc, Carson J. Walker et autres
Abstract Introduction: Patient derived xenografts (PDX) are important preclinical models of cancer as they faithfully recapitulate many aspects of human tumors. Currently, models derived from patients of non-European genetic ancestry are underrepresented, limiting the potential of precision medicine advancements to equitably improve …
us
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Accès ouvert
2025
article
OpenAlex
Andrea N. Riner, Enrique I. Velazquez-Villarreal, Seeta Rajpara, Jing Qian et autres
OBJECTIVES: Black/African American (B/AA) pancreatic ductal adenocarcinoma (PDAC) patients have worse clinical outcomes than White patients and are underrepresented in genomic databases. We aimed to expand our understanding of the PDAC somatic landscape from a diverse cohort. MATERIALS AND METHODS: Formalin-fixed paraffin-embedded …
us
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Accès ouvert
2024
article
OpenAlex
Aslamuzzaman Kazi, Hitesh Vasiyani, Deblina Ghosh, Dipankar Bandyopadhyay et autres
INTRODUCTION: KRAS G12C targeted therapies, such as sotorasib, represent a major breakthrough, but overall response rates and progression-free survival for patients with KRAS G12C lung cancer are modest due to the emergence of resistance mechanisms involving adaptive reactivation of ERK, which requires …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Brian K. Sparkman, Devon C. Freudenberger, Vignesh Vudatha, Jose Trevino et autres
BACKGROUND: Open cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a therapeutic option for the management of malignancies with peritoneal carcinomatosis and of peritoneal origin. Robotic surgery shows promise as a minimally invasive approach for select patients. We aimed to evaluate …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Jennifer B. Permuth, Margaret A. Park, Dung‐Tsa Chen, Toni L. Basinski et autres
Introduction: Cancer-associated cachexia (CC) is a progressive syndrome characterized by unintentional weight loss, muscle atrophy, fatigue, and poor outcomes that affects most patients with pancreatic ductal adenocarcinoma (PDAC). The ability to identify and classify CC stage along its continuum early in the …
us
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