Hui Hong

Characterization of a lytic polysaccharide monooxygenase important for utilization of chitin in Chitinibacter mangrovi FCG-7

黄丽菊, Huimin Fang, Dengfeng Yang, Liyan Yang et autres

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Non-enzymatic acetylation of lysine residues affects the stability of Rubisco activase

Lili Yang, Yanjun Li, Hui Hong, Chunmei Luo et autres

Post-translational modifications of non-histone proteins are critical for plant adaptation to fluctuating environmental conditions. Rubisco activase (RCA), a chloroplastic ATPase, plays a crucial role in CO 2 fixation by activating ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). In this study, we determined that RCA isolated from …

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Associations between cerebral blood transit time, amyloid‐β pathology and cognitive decline in non‐demented older adults

Yao Zhang, Xiao Luo, Hui Hong, Ruiting Zhang et autres

Abstract INTRODUCTION The contribution of cerebrovascular hemodynamic disturbances to Alzheimer's disease (AD) remains unclear. Using time‐shift analysis of blood‐oxygenation‐level‐dependent (BOLD) signals, we explored associations between cerebral blood transit time, amyloid beta (Aβ) pathology, and cognition. METHODS We included 131 non‐demented individuals from …

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Subtype-specific RNA sequencing using micro-dissection revealed extracellular matrix alterations as key factors in lung adenocarcinoma invasion

Chongze Yuan, Xiao Chen, Yizhou Peng, Qiang Zheng et autres

Background: Tumor invasion is a critical step in tumorigenesis and represents an important therapeutic target. However, the molecular mechanisms underlying the invasion process of lung adenocarcinoma (LUAD) remain poorly understood. In this study, we investigated the transcriptomic and epigenetic alterations occurring during …

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Association between choroid plexus features, AD pathology, and cognitive impairment in non-demented participants: a longitudinal study

Lin Miao, Lingyun Liu, Hui Hong, Peiyu Huang

Motivation: Choroid plexus (ChP) disruption may contribute to the progression of Alzheimer's disease (AD). Goal(s): To explore whether ChP structural features are associated with AD pathology and cognitive decline. Approach: Volumetric, shape, and texture ChP features were extracted for correlation and mediation …

Enlargement of perivascular spaces is associated with accelerated Aβ accumulation

Lingyun Liu, Qingze Zeng, Hui Hong, Lin Miao et autres

Motivation: Enlargement of perivascular spaces (PVS) has been found associated with Alzheimer's disease. Goal(s): To explore whether PVS burden modifies the trajectory of Aβ accumulation. Approach: PVS volumes were obtained using an automated PVS segmentation tool, and Aβ deposition was evaluated using …

Characterization of BpLPMO10 from Bacillus paralicheniformis: A bi-functional AA10 LPMO with chitin-preferential activity and strong exo-enzyme synergy

Hui Hong, Xingyue Wang, Dengfeng Yang, X Shao et autres

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Association Between Single Nucleotide Polymorphisms in the Aquaporin‐4 Gene and Longitudinal Changes in White Matter Free Water and Cognitive Function in Non‐Demented Older Adults

Lingyun Liu, Qingze Zeng, Xiao Luo, Hui Hong et autres

We investigated whether aquaporin-4 (AQP4) single-nucleotide polymorphisms (SNPs) influence Alzheimer's disease (AD) progression through changes in the glymphatic system. We included 242 non-dementia participants and chose six SNPs previously shown to be related to AD. We analyzed the associations between AQP4 SNPs …

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Preparation and characterization of Sipunculus nudus peptide-calcium chelate: Structural insights and osteogenic bioactivity assessment

Qianqian Ouyang, Yuwei Jiang, Lifen Liu, Chengfeng Cai et autres

In order to prepare calcium supplements for efficient absorption and utilization in the human body, this study focused on synthesizing SNP-Ca by chelating Squarrosus nudus peptide (SNP) with calcium. We characterized its structure, stability, and calcium uptake properties in Caco-2 cells and …

Spatiotemporal Profiling Unveiling the Cellular Organization Patterns and Local Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma Progression

Haojie Chen, Yizhou Peng, Yana Li, Qiang Zheng et autres

Abstract Spatial cellular organization patterns (COPs) in tumor microenvironment influence the tumor progression and therapeutic response, however, little is known about the cellular composition and functional potential of these multicellular structures during lung adenocarcinoma progression. Here, we integrate spatial transcriptomics with single …

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DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans

Hui Hong, Huicheng Chen, Yuxia Zhang, Zhimao Wu et autres

Coordination of neurite extension with surrounding glia development is critical for neuronal function, but the underlying molecular mechanisms remain poorly understood. Through a genome-wide mutagenesis screen in C. elegans, we identified dyf-4 and daf-6 as two mutants sharing similar defects in dendrite …

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A systematic dissection of the epigenomic heterogeneity of lung adenocarcinoma reveals two different subclasses with distinct prognosis and core regulatory networks

Chongze Yuan, Haojie Chen, Shiqi Tu, Hsin-Yi Huang et autres

BACKGROUND: Lung adenocarcinoma (LUAD) is a highly malignant and heterogeneous tumor that involves various oncogenic genetic alterations. Epigenetic processes play important roles in lung cancer development. However, the variation in enhancer and super-enhancer landscapes of LUAD patients remains largely unknown. To provide …

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