Huimin Fang

Characterization of a lytic polysaccharide monooxygenase important for utilization of chitin in Chitinibacter mangrovi FCG-7

黄丽菊, Huimin Fang, Dengfeng Yang, Liyan Yang et autres

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Aerogel library with varying porous structures and mechanics regulates motor neuron progenitor differentiation for spinal cord injury repair

Jinfei Hou, Junjin Jie, Di Zhang, Jun Chen et autres

The properties of external environment have been acknowledged as important factors influencing cell differentiation. Although efforts have been spared to study the influence of properties on cell differentiation, it is still unknown about how porous structure and mechanics of materials regulate the …

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Heterologous Expression and Biochemical Characterization of a Novel Lytic Polysaccharide Monooxygenase from Chitinilyticum aquatile CSC-1

X Shao, Huimin Fang, Tao Li, Liyan Yang et autres

Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes that catalyze the oxidative cleavage of recalcitrant polysaccharides. There are limited reports on LPMOs capable of concurrently catalyzing the oxidative cleavage of both cellulose and chitin. In this study, we identified and cloned a novel …

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Clay Sculpture‐Inspired 3D Printed Microcage Module Using Bioadhesion Assembly for Specific‐Shaped Tissue Vascularization and Regeneration (Adv. Sci. 21/2024)

Huimin Fang, Jingyi Ju, Lifeng Chen, Muran Zhou et autres

3D Bioprinting In article number 2308381, Zhenxing Wang, Jiaming Sun, and co-worker introduce a novel approach to constructing sizable tissue engineering grafts using a hydrogel with 3D printing and adhesive capabilities, verifying its ability to build tissue engineering grafts in vivo. This …

Clay Sculpture‐Inspired 3D Printed Microcage Module Using Bioadhesion Assembly for Specific‐Shaped Tissue Vascularization and Regeneration

Huimin Fang, Jingyi Ju, Lifeng Chen, Muran Zhou et autres

3D bioprinting techniques have enabled the fabrication of irregular large-sized tissue engineering scaffolds. However, complicated customized designs increase the medical burden. Meanwhile, the integrated printing process hinders the cellular uniform distribution and local angiogenesis. A novel approach is introduced to the construction …

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Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance

Zhibin Zhang, Zhixu Gao, Huimin Fang, Yutang Zhao et autres

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ZIF-8 induced hydroxyapatite-like crystals enabled superior osteogenic ability of MEW printing PCL scaffolds

Bingqian Wang, Yuyang Zeng, Shaokai Liu, Muran Zhou et autres

Abstract ZIF-8 may experience ion-responsive degradation in ionic solutions, which will change its initial architecture and restrict its direct biological use. Herein, we report an abnormal phenomenon in which ZIF-8 induces large hydroxyapatite-like crystals when soaked directly in simulated body fluid. These …

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ZIF-8 induced hydroxyapatite-like crystals enabled superior osteogenic ability of MEW printing PCL scaffolds

Bingqian Wang, Yuyang Zeng, Shaokai Liu, Muran Zhou et autres

Abstract Background In general, ZIF-8 tends to undergo ion responsive degradation in ionic solutions, which makes it difficult to maintain its original structure, thus restricting its direct application in biological settings. Methods ZIF-8 was synthesized using one-pot method and the ZIF-8/PCL scaffolds …

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Djnedd4L Is Required for Head Regeneration by Regulating Stem Cell Maintenance in Planarians

Qingnan Tian, Yujia Sun, Tingting Gao, Jiaxin Li et autres

SUMOylation and ubiquitylation are homologous processes catalyzed by homologous enzymes, and they are involved in nearly all aspects of eukaryotic biology. Planarians, which have the remarkable ability to regenerate their central nervous system (CNS), provide an excellent opportunity to investigate the molecular …

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Preoperative Prognostic Nutrition Index as a Prognostic Indicator of Survival in Elderly Patients Undergoing Gastric Cancer Surgery

Xiaonan Zhang, Huimin Fang, Zhigang Zeng, Kaijun Zhang et autres

PURPOSE: Gastric cancer is a common tumor type associated with nutritional and immune status. The aim of the current study was to investigate the prognostic value of a preoperative prognostic nutritional index (PNI), composed of nutritional factors and immune factors in elderly …

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Simple application of adipose-derived stem cell-derived extracellular vesicles coating enhances cytocompatibility and osteoinductivity of titanium implant

Shan Mou, Jinfei Hou, Huimin Fang, Yuyang Zeng et autres

Surface modification using bioactive molecules is frequently performed to improve the biological properties of medical metal biomaterial titanium (Ti) implants. Developmental evidence suggests that mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) served as potent bioactive component. As a subset of MSC-EV, adipose-derived stem …

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Alendronate loaded graphene oxide functionalized collagen sponge for the dual effects of osteogenesis and anti-osteoclastogenesis in osteoporotic rats

Yuyang Zeng, Muran Zhou, Lifeng Chen, Huimin Fang et autres

Graphene Oxide (GO)-related hydrogels have been extensively studied in hard tissue repair, because GO can not only enhance the mechanical properties of polymers but also promote osteogenic differentiation of mesenchymal stem cells. However, simple GO-related hydrogels are not ideal for the repair …

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