Juliana R. Oliveira

In Silico and in vitro assessment of anti-leishmania infantum activity of a novel cyclohexyl-1,2,4-oxadiazole derivative

Cristian Vicson Gomes Pinheiro, Yasmim Mendes Rocha, João Pedro Viana Rodrigues, Juliana R. Oliveira et autres

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Crotamine derived from Crotalus durissus terrificus venom combined with drugs increases in vitro antibacterial and antifungal activities

Juliana R. Oliveira, Cícera Datiane de Morais Oliveira–Tintino, Joara Nályda Pereira Carneiro, Andressa Guilhermino dos Santos et autres

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Extracellular Domain of IL-10 Receptor Chain-2 (IL-10R2) and Its Arginine-Containing Peptides Are Susceptible Substrates for Human Prostate Kallikrein-2 (KLK2)

Juliana R. Oliveira, José Thalles Lacerda, Tarciso Almeida Sellani, Elaine G. Rodrigues et autres

High Resolution Image Download MS PowerPoint Slide The kallikrein-related peptidase KLK2 has restricted expression in the prostate luminal epithelium, and its protein target is unknown. The present work reports the hydrolytic activities of KLK2 on libraries of fluorescence resonance energy-transfer peptides from …

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Immunological Activity of Vaccine Systems Containing Liposomal Nanocarriers against Protozoan-induced Diseases: A Systematic Review

Francisco Dantas Lourenço, João Victor Lima Teixeira, Gabriel Acácio de Moura, Yasmim Mendes Rocha et autres

Background: Neglected parasitic diseases constitute a broad spectrum of clinical conditions that, in the chronic phase, lack effective therapies for the target population. The utilization of vaccines based on liposomal nanocarrier systems is emerging, thereby enhancing clinical outcomes in various comorbidities. Consequently, …

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Global trend in research conducted on crotamine: a bibliometric analysis

Juliana R. Oliveira, Gabriel Acácio de Moura, João Pedro Viana Rodrigues, Roberto Nicolete

Este estudo investiga a multifuncionalidade do peptídeo crotamina (CTA), ressaltando a necessidade de elucidar temas de pesquisa e promover a cooperação entre publicações, autores, países e agências financiadoras. Foi realizada uma análise bibliométrica para obter insights sobre a produção científica sobre CTA, …

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Antitumor and Antiparasitic Activity of Antimicrobial Peptides Derived from Snake Venom: A Systematic Review Approach

Gabriel Acácio de Moura, Juliana R. Oliveira, Yasmim Mendes Rocha, Janaína de Oliveira Freitas et autres

BACKGROUND: In a scenario of increased pathogens with multidrug resistance phenotypes, it is necessary to seek new pharmacological options. This fact is responsible for an increase in neoplasms and multiresistant parasitic diseases. In turn, snake venom- derived peptides exhibited cytotoxic action on …

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Potential Repurposing of Drugs with Anti-SARS-CoV-2 Activity in Preclinical Trials: A Systematic Review

Yasmim Mendes Rocha, Gabriel Acácio de Moura, Juliana R. Oliveira, Larissa Deadame de Figueiredo Nicolete et autres

COVID-19 is an emerging outbreak similar to previous pandemics caused by Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Till date, SARS-CoV-2 infection is still spreading, representing a major threat to public health, where several control measures are being …

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Abstract 3796: Substrate specificity of human kallikrein-related peptidase 2 (KLK2) towards beta chain of interleukin-10 receptor

LUIZ JOSÉ DA ROCHA NETO, María A. Juliano, Juliana R. Oliveira

Abstract The kallikrein-related peptidases (KLKs) comprise a family of 15 homologous secreted trypsin- or chymotrypsin-like serine proteases. KLK2 and KLK3 have the most organ restricted expression profile of all KLKs; specifically, they are abundantly expressed in the luminal epithelium of the prostate. …

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Active subsite properties, subsite residues and targeting to lysosomes or midgut lumen of cathepsins L from the beetle Tenebrio molitor

Ticiane Fraga Damasceno, Renata O. Dias, Juliana R. Oliveira, Roberto Köpke Salinas et autres

Cathepsins L are the major digestive peptidases in the beetle Tenebrio molitor. Two digestive cathepsins L (TmCAL2 and TmCAL3) from it had their 3D structures solved. The aim of this paper was to study in details TmCAL3 specificity and properties and relate …

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Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?

Roberta N. Silva, Lilian Caroline Gonçalves de Oliveira, Carolina Bellini Parise, Juliana R. Oliveira et autres

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Analysis of the Specificity and Biochemical Characterization of Metalloproteases Isolated from Eupenicillium javanicum Using Fluorescence Resonance Energy Transfer Peptides

Youssef Ali Abou Hamin Neto, Lilian Caroline Gonçalves de Oliveira, Juliana R. Oliveira, María A. Juliano et autres

Enzymes have important features that may facilitate their application in industrial processes and have been used as alternatives to chemical catalysts. In particular, proteases can be isolated from microorganisms, which provide important sources of advantageous enzymes for industrial processes. For example, Eupenicillium …

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Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity Proteins and proteomics

Juliana R. Oliveira, Thiago C. Bertolin, Douglas Andrade, Lilian Caroline Gonçalves de Oliveira et autres

KLK7 substrate specificity was evaluated by families of fluorescence resonance energy transfer (FRET) peptides derived from Abz-KLFSSK-Q-EDDnp (Abz=ortho-aminobenzoic acid and Q-EDDnp=glutaminyl-N-[2,4-dinitrophenyl] ethylenediamine), by one bead-one peptide FRET peptide library in PEGA resin, and by the FRET peptide libraries Abz-GXX-Z-XX-Q-EDDnp (Z and X …