Cristian Vicson Gomes Pinheiro

Descarte inadequado de medicamentos e suas potenciais repercussões para a saúde pública e o meio ambiente: revisão integrativa

Victor Constantino Claudio de Oliveira, Allan da Silva Rebouças, Cailine Ingred Santos Freitas, Maria Janaelvia Guimarães Paiva et autres

O descarte inadequado de medicamentos constitui um problema de relevância sanitária e ambiental, especialmente diante do acúmulo domiciliar de produtos vencidos ou não utilizados e da limitada informação da população sobre sua destinação adequada. Este estudo teve como objetivo analisar as evidências …

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In Silico and in vitro assessment of anti-leishmania infantum activity of a novel cyclohexyl-1,2,4-oxadiazole derivative

Cristian Vicson Gomes Pinheiro, Yasmim Mendes Rocha, João Pedro Viana Rodrigues, Juliana R. Oliveira et autres

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Immunological Activity of Vaccine Systems Containing Liposomal Nanocarriers against Protozoan-induced Diseases: A Systematic Review

Francisco Dantas Lourenço, João Victor Lima Teixeira, Gabriel Acácio de Moura, Yasmim Mendes Rocha et autres

Background: Neglected parasitic diseases constitute a broad spectrum of clinical conditions that, in the chronic phase, lack effective therapies for the target population. The utilization of vaccines based on liposomal nanocarrier systems is emerging, thereby enhancing clinical outcomes in various comorbidities. Consequently, …

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Assessment of differentially expressed genes from in vitro matured human oocytes: A bioinformatics approach

Mayara Lobato Lourenço, Yasmim Mendes Rocha, João Pedro Viana Rodrigues, Cristian Vicson Gomes Pinheiro et autres

OBJECTIVE: One of the techniques that has gained much attention is the in vitro maturation of oocytes for patients who use assisted reproduction techniques. However, its results are still inferior to controlled ovarian stimulation methodologies. Understanding the maturation mechanisms based on analyses …

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Atividade anti-Leishmania spp in silico e in vitro de oxadiazóis sintéticos

Cristian Vicson Gomes Pinheiro

Globally, there are 1 billion people in endemic areas, with over 12 million people infected with leishmaniasis. However, it is a neglected disease, as the affected countries are underdeveloped and the available treatments are old, toxic, requiring a long period of parenteral …

Molecular Dynamics of a N-Cyclohexyl-1,2,4-Oxadiazole Derivative as a Reversible Cruzain Inhibitor in Trypanosoma cruzi

Yasmim Mendes Rocha, Gabriel Acácio de Moura, João Pedro Viana Rodrigues, Cristian Vicson Gomes Pinheiro et autres

Background: Chagas disease kills around 10,000 people yearly, primarily in Latin America, where it is prevalent. Current treatment has limited chronic effectiveness, is unsafe, and has substantial side effects. As a result, the use of oxadiazole derivatives and similar heterocyclic compounds as …

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Anti-Leishmania infantum in vitro effect of n-cyclohexyl-1,2,4-oxadiazole and its ADME/TOX parameters

Cristian Vicson Gomes Pinheiro, Wildson Max Barbosa da Silva, João Pedro Viana Rodrigues, Yasmim Mendes Rocha et autres

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AVALIAÇÃO DOS EFEITOS FARMACOLÓGICOS E ATIVIDADE ANTIDEPRESSIVA DO ÁCIDO GÁLICO EM CAMUNDONGOS

Victor Tabosa dos Santos Oliveira, Juliana de Carvalho Campelo, Cristian Vicson Gomes Pinheiro, Lucas Oliveira Laurino et autres