Koichi Kimura

Hyperperfusion Improvement: A Potential Therapeutic Marker in Neuromyelitis Optica Spectrum Disorder (NMOSD)

Koichi Kimura, Kôji Hayashi, Mamiko Sato, Yuka Nakaya et autres

A 70-year-old Japanese woman with longstanding hearing loss and asthma developed floating sensations, left finger numbness, and postural instability one day after influenza vaccination, leading to hospital admission. Neurological examinations showed hearing loss, hyperreflexia, left-predominant ataxia, bilateral mild bathyanesthesia, and inability to …

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Time-series forecasting for nonlinear high-dimensional system using hybrid method combining autoencoder and multi-parallelized quantum long short-term memory and gated recurrent unit

Makoto Takagi, Ryuji Kokubo, Tsubasa Ikami, Yasuhiro Egami et autres

A time-series forecasting method for high-dimensional spatial data is proposed. The method involves optimal selection of sparse sensor positions to efficiently represent the spatial domain, time-series forecasting at these positions, and estimation of the entire spatial distribution from the forecasted values via …

A Case of Pyogenic Vertebral Osteomyelitis and Iliopsoas Abscess Caused by Invasive Pneumococcal Disease Serotype 35F: Utility of Diffusion-Weighted Whole-Body Imaging With Background Body Signal Suppression as an Adjunctive Diagnostic Tool

Koichi Kimura, Kôji Hayashi, Kosuke Misaki, Mamiko Sato et autres

We present a case of invasive pneumococcal disease (IPD) complicated by both iliopsoas abscess and pyogenic vertebral osteomyelitis caused by serotype 35F Streptococcus pneumoniae in a 64-year-old man with a history of splenectomy who was unvaccinated. The patient experienced difficulty moving, severe …

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Effective Control of Neuropathic Pain With Amitriptyline in Neuromyelitis Optica Spectrum Disorder: A Case Report

Kôji Hayashi, Koichi Kimura, Yuka Nakaya, Asuka Suzuki et autres

We describe a neuromyelitis optica spectrum disorder (NMOSD) case with neuropathic pain (NP) that was successfully controlled by amitriptyline. A 48-year-old woman presented with progressive left lower limb pain, gait disturbance, and sensory deficits, alongside a history of bilateral posterior thigh numbness. …

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Rotigotine Patch is Effective for Levodopa (L-Dopa)-Induced Dyspnea: A Case Report

Koji Hayashi, Yuka Nakaya, Koichi Kimura, M. Sato et autres

Parkinson's disease (PD) is a progressive neurodegenerative disorder with increasing prevalence. While commonly recognized motor symptoms include mobility limitations and balance problems, less attention has been given to respiratory complications related to levodopa (L-dopa) treatment, particularly dyspnea. This report describes an 88-year-old …

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A Case of Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome With Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody: Exploring an Association or Coincidence

Koichi Kimura, Kôji Hayashi, Asuka Suzuki, Mamiko Sato et autres

We report the first documented case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome in a Japanese male with positive serum myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA). The patient, who initially presented with a history of hypertension and cerebral hemorrhage at age …

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Association of Left Atrial Dysfunction with Pulmonary Hemodynamics and Cardiovascular Outcomes in Patients with Systemic Sclerosis

Kazutoshi Hirose, Koki Nakanishi, Masao Daimon, Hikari Seki et autres

Background Left atrial (LA) reservoir strain (LARS) is emerging as an early marker of cardiac remodelling, providing significant prognostic information. The present study investigated the prevalence of LA dysfunction and its association with pulmonary hemodynamics and cardiovascular (CV) outcomes in systemic sclerosis …

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Efficacy of tranilast in preventing exacerbating cardiac function and death from heart failure in muscular dystrophy patients with advanced-stage heart failure: a single-arm, open-label, multicenter study

Tsuyoshi Matsumura, Takayasu Fukudome, Yasufumi Motoyoshi, Akinori Nakamura et autres

BACKGROUND: Transient receptor potential cation channel subfamily V member 2 (TRPV2) functions as a stretch-sensitive calcium channel, with overexpression in the sarcolemma of skeletal and cardiac myocytes leading to detrimental calcium influx and triggering muscle degeneration. In our previous pilot study, we …

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Three-Dimensional Geometry Values and Clinical Determinants for the Annulus of the Tricuspid Valve in a Japanese Population

Rui Ma, Koki Nakanishi, Tomoko Nakao, Megumi Hirokawa et autres

The tricuspid annulus (TA) is the primary target of tricuspid valve (TV) surgery for tricuspid regurgitation (TR). However, the reference values for TA geometry in the Japanese population is currently unavailable. We aimed to elucidate the geometric reference values of the TA …

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CTG repeat length underlying cardiac events and sudden death in myotonic dystrophy type 1

Hideki Itoh, Takashi Hisamatsu, Kazuhiko Segawa, Toshiaki Takahashi et autres

Abstract Aims Myotonic dystrophy Type 1 (DM1) is caused by the expansion of CTG repeats (CTGn) in the DM1 protein kinase (DMPK) gene, while it remains unclear whether CTGn may be associated with the incidence of cardiac events or sudden death in …

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Severe cardiac and skeletal manifestations in DMD-edited microminipigs: an advanced surrogate for Duchenne muscular dystrophy

Masayoshi Otake, Michihiro Imamura, Satoko Enya, Akihisa Kangawa et autres

Duchenne muscular dystrophy (DMD) is an intractable X-linked muscular dystrophy caused by mutations in the DMD gene. While many animal models have been used to study the disease, translating findings to humans has been challenging. Microminipigs, with their pronounced physiological similarity to …

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Clustering Method for Time-Series Images Using Quantum-Inspired Computing Technology

Yu Matsuda, Tomoki Inoue, Koyo Kubota, Tsubasa Ikami et autres

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